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KRAS, NRAS and BRAF mutations in colorectal cancer and melanoma.
Journal article

KRAS, NRAS and BRAF mutations in colorectal cancer and melanoma.

  • Cicenas J Vetsuisse Faculty, Institute of Animal Pathology, University of Bern, 3012, Bern, Switzerland. j.cicenas@mapkinases.eu.
  • Tamosaitis L School of Biosciences, University of Kent, Canterbury, Kent, UK.
  • Kvederaviciute K Institute of Biotechnology, Vilnius University, Saulėtekio ave. 7, LT-01222, Vilnius, Lithuania.
  • Tarvydas R MAP Kinase Resource, Bern, Switzerland.
  • Staniute G MAP Kinase Resource, Bern, Switzerland.
  • Kalyan K MAP Kinase Resource, Bern, Switzerland.
  • Meskinyte-Kausiliene E Aleksandro Stulginskio University, Studentų g. 11, 53361, Akademija, Lithuania.
  • Stankevicius V Lithuania National Cancer Institute, Vilnius, Lithuania.
  • Valius M Proteomics Centre, Vilnius University Institute of Biochemistry, Vilnius, Lithuania.
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  • 2017-01-12
Published in:
  • Medical oncology (Northwood, London, England). - 2017
BRAF
Colorectal cancer
GTPase
KRAS
Kinase
Melanoma
Mutation
NRAS
Squamous cell anal cancer
Animals
Colorectal Neoplasms
GTP Phosphohydrolases
Humans
Melanoma
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins p21(ras)
English Cancers are the group of diseases, which arise because of the uncontrolled behavior of some of the genes in our cells. There are possibilities of gene amplifications, overexpressions, deletions and other anomalies which might lead to the development and spread of cancer. One of the most dangerous ways to the cancers is the mutations of the genes. The mutated genes can start unstoppable proliferation of cells, their uncontrolled motility, protection from apoptosis, the DNA mutation enhancement as well as other anomalies, leading to the cancer. This review focuses on the genes, which are frequently mutated in various cancers and are known to be important in the advance and progression of colorectal cancer and melanoma, namely KRAS, NRAS and BRAF.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/278675
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