Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis.

• Strnad P Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
• Buch S Medical Department 1, University Hospital Dresden, Dresden, Germany.
• Hamesch K Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
• Fischer J Section of Hepatology, Department of Internal Medicine, University Hospital Leipzig, Leipzig, Germany.
• Rosendahl J Section of Hepatology, Department of Internal Medicine, University Hospital Leipzig, Leipzig, Germany.
• Schmelz R Medical Department 1, University Hospital Dresden, Dresden, Germany.
• Brueckner S Medical Department 1, University Hospital Dresden, Dresden, Germany.
• Brosch M Medical Department 1, University Hospital Dresden, Dresden, Germany.
• Heimes CV Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
• Woditsch V Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
• Scholten D Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.
• Nischalke HD Department of Internal Medicine I, University of Bonn, Bonn, Germany.
• Janciauskiene S Clinic for Pneumology, German Center for Lung Research (DZL), Medical University Hannover, Hannover, Germany.
• Mandorfer M Clinic for Gastroenterology und Hepatology, Medical University Vienna, Vienna, Austria.
• Trauner M Clinic for Gastroenterology und Hepatology, Medical University Vienna, Vienna, Austria.
• Way MJ Institute for Liver & Digestive Health, Division of Medicine, Royal Free Campus, University College London, London, UK.
• McQuillin A Molecular Psychiatry Laboratory, Division of Psychiatry, University College London, London, UK.
• Reichert MC Department of Medicine II, Saarland University Medical Center, Homburg, Germany.
• Krawczyk M Department of Medicine II, Saarland University Medical Center, Homburg, Germany.
• Casper M Department of Medicine II, Saarland University Medical Center, Homburg, Germany.
• Lammert F Department of Medicine II, Saarland University Medical Center, Homburg, Germany.
• Braun F Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany.
• von Schönfels W Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany.
• Hinz S Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany.
• Burmeister G Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany.
• Hellerbrand C Institute of Biochemistry, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany.
• Teufel A Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany.
• Feldman A Department of Internal Medicine I, University Hospital Salzburg, Salzburg, Austria.
• Schattenberg JM Department of Medicine I, University Medical Center Mainz, Johannes Gutenberg University, Mainz, Germany.
• Bantel H Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
• Pathil A Department of Internal Medicine IV, Gastroenterology and Hepatology, University of Heidelberg, Heidelberg, Germany.
• Demir M Clinic for Gastroenterology and Hepatology, University Hospital of Cologne, Cologne, Germany.
• Kluwe J I. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
• Boettler T Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
• Ridinger M Department of Psychology, University of Konstanz, Konstanz, Germany.
• Wodarz N Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany.
• Soyka M Psychiatric Hospital, Ludwig Maximilians University, Munich, Germany.
• Rietschel M Faculty of Medicine Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
• Kiefer F Faculty of Medicine Mannheim, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany.
• Weber T Department for Clinical Research, University Hospital Bern, Bern, Switzerland.
• Marhenke S Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
• Vogel A Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
• Hinrichsen H Department of Gastroenterology, University Hospital Kiel, Kiel, Germany.
• Canbay A Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University, Magdeburg, Germany.
• Schlattjan M Department of Gastroenterology and Hepatology, University Duisburg-Essen, Essen, Germany.
• Sosnowsky K Department of Internal Medicine 1, J.W. Goethe University Hospital Frankfurt, Frankfurt, Germany.
• Sarrazin C Department of Internal Medicine 1, J.W. Goethe University Hospital Frankfurt, Frankfurt, Germany.
• von Felden J I. Department of Internal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
• Geier A Division of Hepatology, Department of Medicine II, University Hospital Wuerzburg, Wuerzburg, Germany.
• Deltenre P Division of Gastroenterology and Hepatology, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Lausanne, Switzerland.
• Sipos B Institute of Pathology, University of Tuebingen, Tuebingen, Germany.
• Schafmayer C Department of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Kiel, Germany.
• Nothnagel M Cologne Center for Genomics, University of Cologne, Cologne, Germany.
• Aigner E Department of Internal Medicine I, University Hospital Salzburg, Salzburg, Austria.
• Datz C Department of Internal Medicine, Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg, Oberndorf, Austria.
• Stickel F Department of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland.
• Morgan MY Institute for Liver & Digestive Health, Division of Medicine, Royal Free Campus, University College London, London, UK.
• Hampe J Medical Department 1, University Hospital Dresden, Dresden, Germany.
• Berg T Section of Hepatology, Department of Internal Medicine, University Hospital Leipzig, Leipzig, Germany.
• Trautwein C Medical Clinic III, Gastroenterology, Metabolic Diseases and Intensive Care, University Hospital RWTH Aachen, Aachen, Germany.

Show more…

NASH

SERPINA1

alcoholic liver disease

alpha1-antitrypsin deficiency

fibrosis

Age Distribution

Austria

Biopsy, Needle

Case-Control Studies

Confidence Intervals

Female

Genetic Carrier Screening

Genetic Predisposition to Disease

Genetic Variation

Germany

Heterozygote

Humans

Immunohistochemistry

Incidence

Liver Cirrhosis, Alcoholic

Male

Non-alcoholic Fatty Liver Disease

Odds Ratio

Polymorphism, Single Nucleotide

Prognosis

Risk Assessment

Sex Distribution

alpha 1-Antitrypsin