Journal article
The RAPIDOS project-European and Chinese collaborative research on biomaterials.
- Eglin D AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos Platz, Switzerland.
- Alini M AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos Platz, Switzerland.
- de Bruijn J Xpand Biotechnology B.V., Professor Bronkhorstlaan 10, Building 48, 3723 MB Bilthoven, The Netherlands.
- Gautrot J School of Engineering and Materials Science, Queen Mary University of London, Mile End Road, London E1 4NS, UK.
- Grijpma DW MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
- Kamer L AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos Platz, Switzerland.
- Lai Y Center for Translational Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, China.
- Lu S Institute of Orthopaedics of the General Hospital of the People's Liberation Army, 28 Fuxing Road, Beijing, China.
- Peijs T Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaojiu Road, Shanghai 20001, China.
- Peng J Institute of Orthopaedics of the General Hospital of the People's Liberation Army, 28 Fuxing Road, Beijing, China.
- Tang TT Shanghai Key Laboratory of Orthopedic Implants, Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaojiu Road, Shanghai 20001, China.
- Wang X Center for Translational Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, China.
- Wang X Institute of Orthopaedics of the General Hospital of the People's Liberation Army, 28 Fuxing Road, Beijing, China.
- Richards RG AO Research Institute Davos, Clavadelerstrasse 8, 7270 Davos Platz, Switzerland.
- Qin L Center for Translational Medicine Research and Development, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Avenue, Shenzhen University Town, Shenzhen, China.
- 2018-07-24
Published in:
- Journal of orthopaedic translation. - 2015
English
The research project entitled "rapid prototyping of custom-made bone-forming tissue engineering constructs" (RAPIDOS) is one of the three unique projects that are the result of the first coordinated call for research proposals in biomaterials launched by the European Union Commission and the National Natural Science Foundation of China in 2013 for facilitating bilateral translational research. We formed the RAPIDOS European and Chinese consortium with the aim of applying technologies creating custom-made tissue engineered constructs made of resorbable polymer and calcium phosphate ceramic composites specifically designed by integrating the following: (1) imaging and information technologies, (2) biomaterials and process engineering, and (3) biological and biomedical engineering for novel and truly translational bone repair solutions. Advanced solid free form fabrication technologies, precise stereolithography, and low-temperature rapid prototyping provide the necessary control to create innovative high-resolution medical implants. The use of Chinese medicine extracts, such as the bone anabolic factor icaritin, which has been shown to promote osteogenic differentiation of stem cells and enhance bone healing in vivo, is a safe and technologically relevant alternative to the intensely debated growth factors delivery strategies. This unique initiative driven by a global consortium is expected to accelerate scientific progress in the important field of biomaterials and to foster strong scientific cooperation between China and Europe.
- Language
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- English
- Open access status
- gold
- Identifiers
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- DOI 10.1016/j.jot.2015.02.001
- PMID 30035043
- Persistent URL
- https://sonar.ch/global/documents/278782
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