Back
Systematic Review of In Vivo Animal Models of Subarachnoid Hemorrhage: Species, Standard Parameters, and Outcomes.
Journal article

Systematic Review of In Vivo Animal Models of Subarachnoid Hemorrhage: Species, Standard Parameters, and Outcomes.

  • Marbacher S Department of Neurosurgery c/o Neuro Research Office, Kantonsspital Aarau, Tellstrasse 1, 5001, Aarau, Switzerland. serge.marbacher@ksa.ch.
  • Grüter B Department of Neurosurgery c/o Neuro Research Office, Kantonsspital Aarau, Tellstrasse 1, 5001, Aarau, Switzerland.
  • Schöpf S Department of Neurosurgery c/o Neuro Research Office, Kantonsspital Aarau, Tellstrasse 1, 5001, Aarau, Switzerland.
  • Croci D Department of Neurosurgery c/o Neuro Research Office, Kantonsspital Aarau, Tellstrasse 1, 5001, Aarau, Switzerland.
  • Nevzati E Department of Neurosurgery c/o Neuro Research Office, Kantonsspital Aarau, Tellstrasse 1, 5001, Aarau, Switzerland.
  • D'Alonzo D Department of Neurosurgery c/o Neuro Research Office, Kantonsspital Aarau, Tellstrasse 1, 5001, Aarau, Switzerland.
  • Lattmann J Department of Neurosurgery c/o Neuro Research Office, Kantonsspital Aarau, Tellstrasse 1, 5001, Aarau, Switzerland.
  • Roth T Department of Neurosurgery c/o Neuro Research Office, Kantonsspital Aarau, Tellstrasse 1, 5001, Aarau, Switzerland.
  • Bircher B Department of Neurosurgery c/o Neuro Research Office, Kantonsspital Aarau, Tellstrasse 1, 5001, Aarau, Switzerland.
  • Wolfert C Department of Neurosurgery c/o Neuro Research Office, Kantonsspital Aarau, Tellstrasse 1, 5001, Aarau, Switzerland.
  • Muroi C Department of Neurosurgery c/o Neuro Research Office, Kantonsspital Aarau, Tellstrasse 1, 5001, Aarau, Switzerland.
  • Dutilh G Department of Clinical Research, Clinical Trial Unit, University of Basel Hospital, Basel, Switzerland.
  • Widmer HR Department of Neurosurgery, University Hospital Bern, Bern, Switzerland.
  • Fandino J Department of Neurosurgery c/o Neuro Research Office, Kantonsspital Aarau, Tellstrasse 1, 5001, Aarau, Switzerland.
Show more…
  • 2018-09-14
Published in:
  • Translational stroke research. - 2018
Animal
Delayed cerebral vasospasm
Early brain injury
Model
Subarachnoid hemorrhage
English In preclinical models, modification of experimental parameters associated with techniques of inducing subarachnoid hemorrhage (SAH) can greatly affect outcomes. To analyze how parameter choice affects the relevance and comparability of findings, we systematically reviewed 765 experimental studies of in vivo animal SAH models (2000-2014). During the last decade, we found marked increases in publications using smaller species and models for simulating acute events after SAH. Overall, the fewer types of species and models used did not correlate with an increased standardization in the experimental characteristics and procedures. However, by species, commonly applied, reliable parameters for each experimental SAH technique were identified in mouse, rat, rabbit, and dog models. Our findings can serve as a starting point for discussion toward a more uniform performance of SAH experiments, development of preclinical SAH common data elements, and establishment of standardized protocols for multicenter preclinical trials.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/278787
Statistics
Document views: 57 File downloads: