Journal article
Efficacy of dynamic enhancement effects on Gd-EOB-DTPA-enhanced MRI for estimation of liver function assessed by 13C- Methacetin breath test.
- Probst U Department of Radiology, University Hospital Regensburg, Regensburg, Germany.
- Sieron D Department of Radiology, Inselspital Tiefenau, Bern, Switzerland.
- Bruenn K Department of Radiology, University Hospital Regensburg, Regensburg, Germany.
- Fuhrmann I Department of Radiology, University Hospital Regensburg, Regensburg, Germany.
- Verloh N Department of Radiology, University Hospital Regensburg, Regensburg, Germany.
- Stroszczynski C Department of Radiology, University Hospital Regensburg, Regensburg, Germany.
- Jung EM Department of Radiology, University Hospital Regensburg, Regensburg, Germany.
- Wiggermann P Department of Radiology, University Hospital Regensburg, Regensburg, Germany.
- Haimerl M Department of Radiology, University Hospital Regensburg, Regensburg, Germany.
- 2018-10-30
Published in:
- Clinical hemorheology and microcirculation. - 2018
13C-methacetin liver function breath test
Dynamic contrast enhanced MRI
HCC
abdominal aorta
hepatic parenchyma
liver metastases
portal vein
relative enhancement
signal intensity
Acetamides
Breath Tests
Female
Gadolinium DTPA
Humans
Liver Function Tests
Male
Middle Aged
Retrospective Studies
English
PURPOSE
Contrast enhanced magnetic resonance imaging (MRI) is able to assess liver function by characteristic changes of signal intensity (SI).The aim was to evaluate dynamic contrast-enhanced SI-indices of the abdominal aorta, portal vein and liver.
METHODS
72 patients underwent Gd-EOB-DTPA-enhanced MRI and a 13C-methacetin-based liver breath test (13C-MBT) for evaluation of liver function. Region-of-interest measurements in the liver, abdominal aorta and portal vein during native, arterial (AP), late arterial (LAP), portal venous (PVP) and hepatobiliary phase (HBP) were applied to analyze SI-indices in T1-weighted volume-interpolated breath-hold examination (VIBE) sequences with fat-suppression and relative enhancement (RE) analysis was performed.
RESULTS
The liver (p < 0.001), the portal vein (p < 0.001) and abdominal aorta (p = 0.002) showed significant decrease of REs with decreasing liver function. An increasing trend between logarithmic values of 13C-MBT and REs of hepatic parenchyma (HBP; r = 0.662, p < 0.001), portal vein (PVP; r = 0.532, p < 0.001) and abdominal aorta (PVP; r = 0.421, p < 0.001) was observed.
CONCLUSIONS
RE measurements of the hepatic parenchyma proofed to be a trustable evaluation method for liver function evaluation. In accordance with liver function, changes of REs in the portal vein and abdominal aorta occur.
Contrast enhanced magnetic resonance imaging (MRI) is able to assess liver function by characteristic changes of signal intensity (SI).The aim was to evaluate dynamic contrast-enhanced SI-indices of the abdominal aorta, portal vein and liver.
METHODS
72 patients underwent Gd-EOB-DTPA-enhanced MRI and a 13C-methacetin-based liver breath test (13C-MBT) for evaluation of liver function. Region-of-interest measurements in the liver, abdominal aorta and portal vein during native, arterial (AP), late arterial (LAP), portal venous (PVP) and hepatobiliary phase (HBP) were applied to analyze SI-indices in T1-weighted volume-interpolated breath-hold examination (VIBE) sequences with fat-suppression and relative enhancement (RE) analysis was performed.
RESULTS
The liver (p < 0.001), the portal vein (p < 0.001) and abdominal aorta (p = 0.002) showed significant decrease of REs with decreasing liver function. An increasing trend between logarithmic values of 13C-MBT and REs of hepatic parenchyma (HBP; r = 0.662, p < 0.001), portal vein (PVP; r = 0.532, p < 0.001) and abdominal aorta (PVP; r = 0.421, p < 0.001) was observed.
CONCLUSIONS
RE measurements of the hepatic parenchyma proofed to be a trustable evaluation method for liver function evaluation. In accordance with liver function, changes of REs in the portal vein and abdominal aorta occur.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.3233/CH-189324
- PMID 30372671
- Persistent URL
- https://sonar.ch/global/documents/278822
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