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Encapsulation of polyphenols into pHEMA e-spun fibers and determination of their antioxidant activities.
Journal article

Encapsulation of polyphenols into pHEMA e-spun fibers and determination of their antioxidant activities.

  • Ghitescu RE Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Protection and Physiology, Lerchenfeldstrasse 5, St. Gallen 9014, Switzerland; Gheorghe Asachi Technical University, Faculty of Chemical Engineering and Environmental Protection, 71 A Mangeron Blvd., Iasi 700050, Romania.
  • Popa AM Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Protection and Physiology, Lerchenfeldstrasse 5, St. Gallen 9014, Switzerland.
  • Popa VI Gheorghe Asachi Technical University, Faculty of Chemical Engineering and Environmental Protection, 71 A Mangeron Blvd., Iasi 700050, Romania.
  • Rossi RM Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Protection and Physiology, Lerchenfeldstrasse 5, St. Gallen 9014, Switzerland.
  • Fortunato G Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Protection and Physiology, Lerchenfeldstrasse 5, St. Gallen 9014, Switzerland. Electronic address: giuseppino.fortunato@empa.ch.
  • 2015-08-18
Published in:
  • International journal of pharmaceutics. - 2015
Antioxidant activity
Controlled release
Electrospinning
Nanofibers
Polyphenols
Antioxidants
Drug Liberation
Nanofibers
Picea
Plant Bark
Plant Extracts
Polyhydroxyethyl Methacrylate
Polyphenols
Vanillic Acid
English This study reports on the development of electrospun poly(2-hydroxyethyl methacrylate) (pHEMA) fibers loaded with synthetic and natural antioxidants in the form of selected types of polyphenols such as vanillic, gallic, syringic acids, catechin or natural spruce bark extract to investigate their release behavior in terms of antioxidant activities. Homogenous fiber morphologies were obtained at specified concentration ranges of pHEMA within the spinning solutions, exhibiting fiber diameters in the range from 0.5±0.1 μm to 1.9±0.5 μm. The addition of polyphenols resulted in an increase of fiber diameters with increasing concentration of additives. This is attributed to the effect of hydrogen bonding between the active ingredients and the polymeric matrix, increasing shear viscosities and thus hindering effective drawing processes during fiber formation. Polyphenol release measurement gave high release rates in a first phase followed by a smooth release at long term. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay, used to monitor antioxidant activity, showed that polyphenols had retained their activity after incorporation into the pHEMA nanofibers. Furthermore, it was demonstrated that the encapsulation of polyphenols in pHEMA nanofibers can delay to a high extent their degradation induced by environmental factors.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/278865
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