The Sulfinator: predicting tyrosine sulfation sites in protein sequences.
- Monigatti F SWISS-PROT Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
- Gasteiger E
- Bairoch A
- Jung E
- 2002-06-07
Published in:
- Bioinformatics (Oxford, England). - 2002
Amino Acid Sequence
Animals
Caenorhabditis elegans
Database Management Systems
Databases, Protein
Drosophila
Humans
Molecular Sequence Data
Proteins
Sensitivity and Specificity
Sequence Alignment
Sequence Analysis, Protein
Software
Sulfates
Tyrosine
English
UNLABELLED
Protein tyrosine sulfation is an important post-translational modification of proteins that go through the secretory pathway. No clear-cut acceptor motif can be defined that allows the prediction of tyrosine sulfation sites in polypeptide chains. The Sulfinator is a software tool that can be used to predict tyrosine sulfation sites in protein sequences with an overall accuracy of 98%. Four different Hidden Markov Models were constructed, each of them specialized to recognize sulfated tyrosine residues depending on their location within the sequence: near the N-terminus, near the C-terminus, in the center of a window with a size of at least 25 amino acids, as well as in windows containing several tyrosine residues.
AVAILABILITY
The Sulfinator is accessible at (http://www.expasy.org/tools/sulfinator/).
SUPPLEMENTARY INFORMATION
Sulfinator documentation is accessible at (http://www.expasy.org/tools/sulfinator/sulfinator-doc.html).
Protein tyrosine sulfation is an important post-translational modification of proteins that go through the secretory pathway. No clear-cut acceptor motif can be defined that allows the prediction of tyrosine sulfation sites in polypeptide chains. The Sulfinator is a software tool that can be used to predict tyrosine sulfation sites in protein sequences with an overall accuracy of 98%. Four different Hidden Markov Models were constructed, each of them specialized to recognize sulfated tyrosine residues depending on their location within the sequence: near the N-terminus, near the C-terminus, in the center of a window with a size of at least 25 amino acids, as well as in windows containing several tyrosine residues.
AVAILABILITY
The Sulfinator is accessible at (http://www.expasy.org/tools/sulfinator/).
SUPPLEMENTARY INFORMATION
Sulfinator documentation is accessible at (http://www.expasy.org/tools/sulfinator/sulfinator-doc.html).
- Language
-
- English
- Open access status
- bronze
- Identifiers
-
- DOI 10.1093/bioinformatics/18.5.769
- PMID 12050077
- Persistent URL
- https://sonar.ch/global/documents/278899
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