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Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland: Findings from an International Workshop.
Journal article

Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland: Findings from an International Workshop.

  • Nikolaidis C Institute of Nursing Science, Department of Public Health, University of Basel, Basel, Switzerland.
  • Ming C Institute of Nursing Science, Department of Public Health, University of Basel, Basel, Switzerland.
  • Pedrazzani C Institute of Nursing Science, Department of Public Health, University of Basel, Basel, Switzerland.
  • van der Horst T Institute of Nursing Science, Department of Public Health, University of Basel, Basel, Switzerland.
  • Kaiser-Grolimund A Institute of Nursing Science, Department of Public Health, University of Basel, Basel, Switzerland.
  • Ademi Z European Center of Pharmaceutical Medicine, University of Basel, Basel, Switzerland.
  • Bührer-Landolt R University Clinic for Medical Oncology, Inselspital Bern, Bern, Switzerland.
  • Bürki N Women's Clinic and Gynecological Oncology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Caiata-Zufferey M University of Applied Sciences and Arts of Southern Switzerland, Manno, Switzerland.
  • Champion V Indiana University School of Nursing, Indianapolis, Indiana, USA.
  • Chappuis PO Division of Genetic Medicine, Geneva University Hospitals, University of Geneva, Geneva, Switzerland.
  • Kohler C Institute of Nursing Science, Department of Public Health, University of Basel, Basel, Switzerland.
  • Erlanger TE Clinical Trial Unit, Department of Clinical Research, University Hospital Basel, Basel, Switzerland.
  • Graffeo R Institute of Oncology and Breast Unit of Southern Switzerland, Bellinzona, Switzerland.
  • Hampel H Division of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus, Ohio, USA.
  • Heinimann K Institute for Medical Genetics and Pathology, University Hospital Basel, and Research Group Human Genomics, Department of Biomedicine, University of Basel, Basel, Switzerland.
  • Heinzelmann-Schwarz V Women's Clinic and Gynecological Oncology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Kurzeder C Women's Clinic and Gynecological Oncology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Monnerat C Oncology Services, Hospital of Jura, Delémont, Switzerland.
  • Northouse LL University of Michigan School of Nursing, Ann Arbor, Michigan, USA.
  • Pagani O Institute of Oncology and Breast Unit of Southern Switzerland, Bellinzona, Switzerland.
  • Probst-Hensch N Swiss Tropical and Public Health Institute, University of Basel, Basel, Switzerland.
  • Rabaglio M University Clinic for Medical Oncology, Inselspital Bern, Bern, Switzerland.
  • Schoenau E Women's Clinic and Gynecological Oncology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Sijbrands EJG Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
  • Taborelli M Institute of Oncology and Breast Unit of Southern Switzerland, Bellinzona, Switzerland.
  • Urech C Women's Clinic and Gynecological Oncology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Viassolo V Unit of Oncogenetics and Cancer Prevention, Division of Oncology, Geneva University Hospitals, Geneva, Switzerland.
  • Wieser S Winterthur Institute of Health Economics, Zurich University of Applied Sciences, Winterthur, Switzerland.
  • Katapodi MC Institute of Nursing Science, Department of Public Health, University of Basel, Basel, Switzerland, maria.katapodi@unibas.ch.
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  • 2019-01-30
Published in:
  • Public health genomics. - 2018
English BACKGROUND
An international workshop on cancer predisposition cascade genetic screening for hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) took place in Switzerland, with leading researchers and clinicians in cascade screening and hereditary cancer from different disciplines. The purpose of the workshop was to enhance the implementation of cascade genetic screening in Switzerland. Participants discussed the challenges and opportunities associated with cascade screening for HBOC and LS in Switzerland (CASCADE study); family implications and the need for family-based interventions; the need to evaluate the cost-effectiveness of cascade genetic screening; and interprofessional collaboration needed to lead this initiative.


METHODS
The workshop aims were achieved through exchange of data and experiences from successful cascade screening programs in the Netherlands, Australia, and the state of Ohio, USA; Swiss-based studies and scientific experience that support cancer cascade screening in Switzerland; programs of research in psychosocial oncology and family-based studies; data from previous cost-effectiveness analyses of cascade genetic screening in the Netherlands and in Australia; and organizational experience from a large interprofessional collaborative. Scientific presentations were recorded and discussions were synthesized to present the workshop findings.


RESULTS
The key elements of successful implementation of cascade genetic screening are a supportive network of stakeholders and connection to complementary initiatives; sample size and recruitment of relatives; centralized organization of services; data-based cost-effectiveness analyses; transparent organization of the initiative; and continuous funding.


CONCLUSIONS
This paper describes the processes and key findings of an international workshop on cancer predisposition cascade screening, which will guide the CASCADE study in Switzerland.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/279023
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