A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition.

• Li D F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
• Achkar JP Department of Gastroenterology and Hepatology, Cleveland Clinic, Cleveland, Ohio.
• Haritunians T F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
• Jacobs JP Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
• Hui KY Division of Gastroenterology, Department of Medicine, Yale University, New Haven, Connecticut.
• D'Amato M Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden; Biocruces Health Research Institute, Barakaldo, Bizkaia, Spain.
• Brand S Department of Medicine II, University Hospital Munich-Grosshadern, Munich, Germany.
• Radford-Smith G Inflammatory Bowel Diseases, Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia; Department of Gastroenterology, Royal Brisbane and Women's Hospital, Brisbane, Australia; School of Medicine, University of Queensland, Brisbane, Australia.
• Halfvarson J Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Orebro, Sweden.
• Niess JH Department of Internal Medicine I, University of Ulm, Ulm, Germany; Division of Visceral Surgery and Medicine, Department of Gastroenterology, Inselspital Bern, Bern, Switzerland; Gastroenterology and Hepatology, University Hospital Basel, Basel, Switzerland.
• Kugathasan S Department of Pediatrics, Emory University School of Medicine and Children's Health Care of Atlanta, Atlanta, Georgia.
• Büning C Internal Medicine, Krankenhaus Waldfriede, Berlin, Germany.
• Schumm LP Department of Public Health Sciences, Biostatistical Laboratory, University of Chicago, Chicago, Illinois.
• Klei L Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
• Ananthakrishnan A Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
• Aumais G Université de Montréal, Montréal, Québec, Canada; Hopital Maisonneuve Rosemont, Montréal, Québec, Canada.
• Baidoo L Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
• Dubinsky M F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California; Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York.
• Fiocchi C Pathobiology Department, Cleveland Clinic, Cleveland, Ohio.
• Glas J Department of Preventive Dentistry and Periodontology, Ludwig-Maximilians-University, Munich, Germany.
• Milgrom R Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
• Proctor DD Division of Gastroenterology, Department of Medicine, Yale University, New Haven, Connecticut.
• Regueiro M Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
• Simms LA Inflammatory Bowel Diseases, Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
• Stempak JM Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
• Targan SR F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
• Törkvist L Department of Clinical Science Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; Center for Digestive Disease, IBD-unit, Karolinska University Hospital, Stockholm, Sweden.
• Sharma Y Department of Genetic & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
• Devlin B Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania.
• Borneman J Department of Plant Pathology and Microbiology, University of California, Riverside, Riverside, California.
• Hakonarson H Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
• Xavier RJ Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
• Daly M Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.
• Brant SR Division of Gastroenterology and Hepatology, School of Medicine, Johns Hopkins University, Baltimore, Maryland; Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland.
• Rioux JD Université de Montréal, Montréal, Québec, Canada; Montreal Heart Institute, Montréal, Québec, Canada.
• Silverberg MS Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.
• Cho JH Department of Genetic & Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York; Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
• Braun J Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
• McGovern DP F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.
• Duerr RH Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: duerr@pitt.edu.

Show more…

Genetics

Inflammatory Bowel Diseases

Microbiota

Alleles

Case-Control Studies

Cation Transport Proteins

Colitis, Ulcerative

Crohn Disease

Female

Gastrointestinal Microbiome

Genetic Pleiotropy

Genotype

Humans

Male

Mutation, Missense

Risk Factors