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Journal article

Renin-angiotensin system and SARS-CoV-2 interaction: underlying mechanisms and potential clinical implications.

  • Hrenak J Department of Cardiovascular Surgery, Inselspital - University Hospital of Bern, Bern, Switzerland.
  • Zorad S
  • Simko F
  • 2020-06-12
Published in:
  • General physiology and biophysics. - 2020
Angiotensin II
Angiotensin II Type 1 Receptor Blockers
Angiotensin-Converting Enzyme Inhibitors
Betacoronavirus
Cardiovascular Diseases
Coronavirus Infections
Humans
Pandemics
Peptidyl-Dipeptidase A
Pneumonia, Viral
Renin-Angiotensin System
Virus Internalization
English Renin-angiotensin system (RAS) inhibition supposedly increases the expression of angiotensin converting enzyme 2, serving as a binding site for SARS-CoV-2. Concerns arose regarding therapy with RAS inhibition during the COVID-19 pandemic. However, the pharmacological restraining the classical RAS axis might be beneficial due to the reduction of deleterious effects of angiotensin II and enhancement of the anti-inflammatory angiotensin 1-7 pathway. Unless large controlled studies are performed, RAS inhibition remains the cornerstone therapy in populations with cardiovascular disorders.
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  • English
Open access status
bronze
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https://sonar.ch/global/documents/279101
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