Back
Practical aspects of genetic counseling in breast cancer: lights and shadows.
Journal article

Practical aspects of genetic counseling in breast cancer: lights and shadows.

  • Christinat A Institute of Oncology of Southern Switzerland, Bellinzona, Switzerland. alexandre.christinat@eoc.ch
  • Pagani O
  • 2013-05-16
Published in:
  • Breast (Edinburgh, Scotland). - 2013
Antigens, CD
Breast Neoplasms
Breast Neoplasms, Male
Cadherins
Female
Genes, BRCA1
Genes, BRCA2
Genes, p53
Genetic Counseling
Genetic Predisposition to Disease
Genetic Testing
Hamartoma Syndrome, Multiple
Hereditary Breast and Ovarian Cancer Syndrome
Humans
Li-Fraumeni Syndrome
Male
Mastectomy
Mutation
Neoplastic Syndromes, Hereditary
PTEN Phosphohydrolase
Peutz-Jeghers Syndrome
Protein-Serine-Threonine Kinases
English In unselected populations, less than 10% of breast cancers are associated with germline mutations in predisposing genes. Breast cancer type 1 and 2 (BRCA1 and BRCA2) susceptibility genes are the most common involved genes and confer a 10-30 times higher risk of developing the disease compared to the general population. A personal or family history suggestive of inherited breast cancer syndrome may be further evaluated to assess the risk of genetic predisposition and the presence of a genetic mutation. Breast cancer genetic counseling should include a careful risk assessment with associated psychosocial evaluation and support, possible molecular testing, personalized discussion of results. Knowledge of BRCA status can influence individualized cancer risk-reduction strategies. i.e. active surveillance, prophylactic surgery and/or pharmacoprevention.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/279170
Statistics
Document views: 48 File downloads: