Journal article
Exploring Modular Glycolipids Involved in Nematode Chemical Communication.
- von Reuss SH Laboratory for Bioanalytical Chemistry University of Neuchâtel Avenue de Bellevaux 51, Neuchâtel, Switzerland;, Email: stephan.vonreuss@unine.ch.
- 2018-05-24
Published in:
- Chimia. - 2018
English
Chemical communication in nematodes has been known for over half a century, but the underlying molecular basis remained largely elusive. Recent advances in analytical techniques facilitated the characterization of a modular glycolipid library based on the dideoxysugar L-ascarylose, which modulates behavior and development in the model organism C. elegans. Ascaroside signaling is highly conserved in nematodes and represents a key factor in nematode chemical ecology. Ascaroside biosynthesis depends on the co-option of the peroxisomal β-oxidation cycle and in addition integrates a large diversity of additional building blocks derived from various primary metabolic pathways to give rise to species-specific modular assemblies, thus, transcending the concept of strictly segregated primary versus secondary metabolism.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.2533/chimia.2018.297
- PMID 29789066
- Persistent URL
- https://sonar.ch/global/documents/281061
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