Journal article
Mass spectrometry-based antigen discovery for cancer immunotherapy.
- Bassani-Sternberg M Ludwig Institute for Cancer Research, University of Lausanne Branch & Department of Oncology, CHUV, Lausanne, Switzerland. Electronic address: michal.bassani@chuv.ch.
- Coukos G Ludwig Institute for Cancer Research, University of Lausanne Branch & Department of Oncology, CHUV, Lausanne, Switzerland.
- 2016-05-08
Published in:
- Current opinion in immunology. - 2016
English
The antigenic landscape of tumors is distinct from healthy cells and has been the rationale behind a variety of vaccination trials. Typically the target tumor-associated antigens have been of self origin and have rarely induced effective anti-tumor responses. Recent data show that activation of the immune system by immune checkpoint blocking therapies leads to tumor rejection and that recognition of mutated antigens, known as 'neo-antigens' plays a key role. Discovery of neo-antigens relies mainly on prediction-based interrogation of the 'mutanome' using genomic information as input, followed by T-cell screening. Recent breakthroughs in mass spectrometry (MS) based immunopeptidomics have allowed the discovery of very large pools of naturally presented peptides, among them neo-epitopes. This review highlights the current progress related to neo-antigens discovery with emphasis on prediction algorithms and MS as well as the synergy of the two methodologies and how they can be exploited to develop effective personalized immunotherapy.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.coi.2016.04.005
- PMID 27155075
- Persistent URL
- https://sonar.ch/global/documents/281314
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