One-Pot Synthesis of 1-[(Triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one (TIPS-EBX): Process Safety Assessment and Impact of Impurities on Product Stability

Hari, Durga Prasad Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fedérale de Lausanne, EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland
Caramenti, Paola Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fedérale de Lausanne, EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland
Schouwey, Lionel Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fedérale de Lausanne, EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland
Chang, Miyeon Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fedérale de Lausanne, EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland
Nicolai, Stefano Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fedérale de Lausanne, EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland
Bachert, Donald Chemical Engineering R&D, Merck & Co., Inc., Rahway, New Jersey 07065, United States
Wright, Timothy Chemical Engineering R&D, Merck & Co., Inc., Rahway, New Jersey 07065, United States
Orella, Chuck Chemical Engineering R&D, Merck & Co., Inc., Rahway, New Jersey 07065, United States
Waser, Jerome ORCID Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fedérale de Lausanne, EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland