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Producing Radical-Free Hyperpolarized Perfusion Agents for In Vivo Magnetic Resonance Using Spin-Labeled Thermoresponsive Hydrogel.
Journal article

Producing Radical-Free Hyperpolarized Perfusion Agents for In Vivo Magnetic Resonance Using Spin-Labeled Thermoresponsive Hydrogel.

  • Cheng T Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne, Station 6, 1015, Lausanne, Switzerland.
  • Mishkovsky M Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Station 6, 1015, Lausanne, Switzerland.
  • Junk MJ Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
  • Münnemann K Max Planck Institute for Polymer Research, Ackermannweg 10, 55128, Mainz, Germany.
  • Comment A Institute of Physics of Biological Systems, Ecole Polytechnique Fédérale de Lausanne, Station 6, 1015, Lausanne, Switzerland.
  • 2016-05-18
Published in:
  • Macromolecular rapid communications. - 2016
carbon-13 MRS
dynamic nuclear polarization
radical-free
spin-labeled thermoresponsive hydrogels
Carbon Isotopes
Free Radicals
Hydrogel, Polyethylene Glycol Dimethacrylate
Magnetic Resonance Spectroscopy
Perfusion
Temperature
tert-Butyl Alcohol
English Dissolution dynamic nuclear polarization (DNP) provides a way to tremendously improve the sensitivity of nuclear magnetic resonance experiments. Once the spins are hyperpolarized by dissolution DNP, the radicals used as polarizing agents become undesirable since their presence is an additional source of nuclear spin relaxation and their toxicity might be an issue. This study demonstrates the feasibility of preparing a hyperpolarized [1-(13) C]2-methylpropan-2-ol (tert-butanol) solution free of persistent radicals by using spin-labeled thermoresponsive hydrophilic polymer networks as polarizing agents. The hyperpolarized (13) C signal can be detected for up to 5 min before the spins fully relax to their thermal equilibrium. This approach extends the applicability of spin-labeled thermoresponsive hydrogel to the dissolution DNP field and highlights its potential as polarizing agent for preparing neat slowly relaxing contrast agents. The hydrogels are especially suited to hyperpolarize deuterated alcohols which can be used for in vivo perfusion imaging.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/282267
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