Journal article

Ocular Mucous Membrane Pemphigoid: Current State of Pathophysiology, Diagnostics and Treatment.

  • Georgoudis P Whipps Cross University Hospital, Barts Health NHS Trust, London, UK.
  • Sabatino F Moorfields Eye Hospital, London, UK.
  • Szentmary N Department of Ophthalmology, Saarland University Medical Center, Homburg/Saar, Germany.
  • Palioura S Athens Vision Eye Institute, Athens, Greece.
  • Fodor E Department of Ophthalmology, Semmelweis University, Budapest, Hungary.
  • Hamada S Corneo-Plastic Unit, Queen Victoria Hospital, East Grinstead, UK.
  • Scholl HPN Department of Ophthalmology, Basel University Hospital, Basel, Switzerland.
  • Gatzioufas Z Department of Ophthalmology, Basel University Hospital, Basel, Switzerland. zisisg@hotmail.com.
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  • 2019-01-30
Published in:
  • Ophthalmology and therapy. - 2019
English Mucous membrane pemphigoid (MMP) is a systemic cicatrizing autoimmune disease that primarily affects orificial mucous membranes, such as the conjunctiva, the nasal cavity, the oropharynx, and the genitalia. Ocular involvement occurs in about 70% of all MMP cases. Ocular MMP (OcMMP) also encompasses the conditions linear immunoglobulin A disease, mucosal dominated epidermolysis bullosa acquisita, and anti-laminin 332/anti-epiligrin/anti-laminin 5 pemphigoid. It is a complex clinical entity that may lead to ocular surface failure and result in inflammatory and infectious complications, as well as potentially devastating visual loss. Early diagnosis and appropriate treatment are of paramount importance and require a high level of expertise as this condition can be extremely challenging to diagnose and treat even for experienced clinicians. In this review we provide an up-to-date insight on the pathophysiology of OcMMP, with an emphasis on the current state of its diagnostics and therapeutics. Our the aim is to increase our understanding of OcMMP and highlight modern diagnostic and therapeutic options.
Language
  • English
Open access status
gold
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Persistent URL
https://sonar.ch/global/documents/282570
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