Clinical presentation and outcome across age categories among patients with COVID-19 admitted to a Spanish Emergency Department.
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Martín-Sánchez FJ
Department of Emergency, Hospital Clínico San Carlos, Calle Profesor Martín-Lagos s/n, 28040, Madrid, Spain. fjjms@hotmail.com.
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Del Toro E
Department of Emergency, Hospital Clínico San Carlos, Calle Profesor Martín-Lagos s/n, 28040, Madrid, Spain.
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Cardassay E
Department of Emergency, Hospital Clínico San Carlos, Calle Profesor Martín-Lagos s/n, 28040, Madrid, Spain.
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Valls Carbó A
Department of Neurology, Hospital Clínico San Carlos, Madrid, Spain.
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Cuesta F
Department of Geriatric, Hospital Clínico San Carlos, Madrid, Spain.
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Vigara M
Department of Geriatric, Hospital Clínico San Carlos, Madrid, Spain.
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Gil P
Department of Geriatric, Hospital Clínico San Carlos, Madrid, Spain.
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López Picado AL
Institute for Health Research of Hospital San Carlos, Madrid, Spain.
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Martínez Valero C
Institute for Health Research of Hospital San Carlos, Madrid, Spain.
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Miranda JD
Risk Modelling Division of Repsol, Madrid, Spain.
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Lopez-Ayala P
Cardiovascular Research Institute Basel (CRIB), Department of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland.
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Chaparro D
Department of Emergency, Hospital Clínico San Carlos, Calle Profesor Martín-Lagos s/n, 28040, Madrid, Spain.
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Cozar López G
Department of Emergency, Hospital Clínico San Carlos, Calle Profesor Martín-Lagos s/n, 28040, Madrid, Spain.
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Del Mar Suárez-Cadenas M
Department of Emergency, Hospital Clínico San Carlos, Calle Profesor Martín-Lagos s/n, 28040, Madrid, Spain.
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Jerez Fernández P
Department of Emergency, Hospital Clínico San Carlos, Calle Profesor Martín-Lagos s/n, 28040, Madrid, Spain.
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Angós B
Department of Emergency, Hospital Clínico San Carlos, Calle Profesor Martín-Lagos s/n, 28040, Madrid, Spain.
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Díaz Del Arco C
Department of Pathological Anatomy, Hospital Clínico San Carlos, Madrid, Spain.
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Rodríguez Adrada E
Institute for Health Research of Hospital San Carlos, Madrid, Spain.
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Montalvo Moraleda MT
Department of Neurology, Hospital Clínico San Carlos, Madrid, Spain.
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Espejo Paeres C
Department of Cardiology, Hospital Clínico San Carlos, Madrid, Spain.
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Fernández Alonso C
Department of Emergency, Hospital Clínico San Carlos, Calle Profesor Martín-Lagos s/n, 28040, Madrid, Spain.
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Elvira C
Department of Admissions and Clinical Documentation, Hospital Clínico San Carlos, Madrid, Spain.
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Chacón A
Department of Admissions and Clinical Documentation, Hospital Clínico San Carlos, Madrid, Spain.
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García Briñón MÁ
Department of Emergency, Hospital Clínico San Carlos, Calle Profesor Martín-Lagos s/n, 28040, Madrid, Spain.
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Fernández Rueda JL
Department of Information Systems and Technologies, Hospital Clínico San Carlos, Madrid, Spain.
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Ortega L
Department of Pathological Anatomy, Hospital Clínico San Carlos, Madrid, Spain.
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Fernández Pérez C
Department of Preventive Medicine, Hospital Clínico San Carlos, Madrid, Spain.
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González Armengol JJ
Department of Emergency, Hospital Clínico San Carlos, Calle Profesor Martín-Lagos s/n, 28040, Madrid, Spain.
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González Del Castillo J
Department of Emergency, Hospital Clínico San Carlos, Calle Profesor Martín-Lagos s/n, 28040, Madrid, Spain.
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Published in:
- European geriatric medicine. - 2020
English
PURPOSE
To determine the differences by age-dependent categories in the clinical profile, presentation, management, and short-term outcomes of patients with laboratory-confirmed COVID-19 admitted to a Spanish Emergency Department (ED).
METHODS
Secondary analysis of COVID-19_URG-HCSC registry. We included all consecutive patients with laboratory-confirmed COVID-19 admitted to the ED of the University Hospital Clinico San Carlos (Madrid, Spain). The population was divided into six age groups. Demographic, baseline and acute clinical data, and in-hospital and 30-day outcomes were collected.
RESULTS
1379 confirmed COVID-19 cases (mean age 62 (SD 18) years old; 53.5% male) were included (18.1% < 45 years; 17.8% 45-54 years; 17.9% 55-64 years; 17.2% 65-74 years; 17.0% 75-84 years; and 11.9% ≥ 85 years). A statistically significant association was found between demographic, comorbidity, clinical, radiographic, analytical, and therapeutic variables and short-term results according to age-dependent categories. There were less COVID-specific symptoms and more atypical symptoms among older people. Age was a prognostic factor for hospital admission (aOR = 1.04; 95% CI 1.02-1.05) and in-hospital (aOR = 1.08; 95% CI 1.05-1.10) and 30-day mortality (aOR = 1.07; 95% CI 1.04-1.09), and was associated with not being admitted to intensive care (aOR = 0.95; 95% CI 0.93-0.98).
CONCLUSIONS
Older age is associated with less COVID-specific symptoms and more atypical symptoms, and poor short-term outcomes. Age has independent prognostic value and may help in shared decision-making in patients with confirmed COVID-19 infection.
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Language
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Open access status
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bronze
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Identifiers
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Persistent URL
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https://sonar.ch/global/documents/282859
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