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Bone-marrow haematopoietic-stem-cell niches.
Journal article

Bone-marrow haematopoietic-stem-cell niches.

  • Wilson A Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Chemin des Boveresses 155, 1066 Epalinges, Switzerland.
  • Trumpp A
  • 2006-02-24
Published in:
  • Nature reviews. Immunology. - 2006
Animals
Bone Marrow
Cell Differentiation
Hematopoietic Stem Cells
Homeostasis
Humans
Models, Immunological
English Adult stem cells hold many promises for future clinical applications and regenerative medicine. The haematopoietic stem cell (HSC) is the best-characterized somatic stem cell so far, but in vitro expansion has been unsuccessful, limiting the future therapeutic potential of these cells. Here we review recent progress in characterizing the composition of the HSC bone-marrow microenvironment, known as the HSC niche. During homeostasis, HSCs, and therefore putative bone-marrow HSC niches, are located near bone surfaces or are associated with the sinusoidal endothelium. The molecular crosstalk between HSCs and the cellular constituents of these niches is thought to control the balance between HSC self-renewal and differentiation, indicating that future successful expansion of HSCs for therapeutic use will require three-dimensional reconstruction of a stem-cell-niche unit.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/282999
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