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PPARs at the crossroads of lipid signaling and inflammation.
Journal article

PPARs at the crossroads of lipid signaling and inflammation.

  • Wahli W Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, Le Génopode, CH-1015 Lausanne, Switzerland. walter.wahli@unil.ch
  • Michalik L
  • 2012-06-19
Published in:
  • Trends in endocrinology and metabolism: TEM. - 2012
Animals
Humans
Inflammation
Lipid Metabolism
Peroxisome Proliferator-Activated Receptors
English Nuclear receptors (NRs) are ligand-dependent transcription factors whose activation affects genes controlling vital processes. Among them, the peroxisome proliferator-activated receptors (PPARs) have emerged as links between lipids, metabolic diseases, and innate immunity. PPARs are activated by fatty acids and their derivatives, many of which also signal through membrane receptors, thereby creating a lipid signaling network between the cell surface and the nucleus. Tissues that play a role in whole-body metabolic homeostasis, such as adipose tissue, liver, skeletal muscle, intestines, and blood vessel walls, are prone to inflammation when metabolism is disturbed, a complication that promotes type 2 diabetes and cardiovascular disease. This review discusses the protective roles of PPARs in inflammatory conditions and the therapeutic anti-inflammatory potential of PPAR ligands.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/283268
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