Vaccination against Allergy: A Paradigm Shift?
- Bachmann MF Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Department of BioMedical Research, Immunology RIA, Inselspital, University of Bern, Bern, Switzerland.
- Mohsen MO Department of BioMedical Research, Immunology RIA, Inselspital, University of Bern, Bern, Switzerland; National Centre for Cancer Care & Research (NCCCR), Doha, State of Qatar.
- Kramer MF Allergy Therapeutics (UK) Ltd, Dominion Way, Worthing, UK; Bencard Allergie GmbH, Leopoldstrasse, Munich, Germany; Bencard Adjuvant Systems (a division of Allergy Therapeutics), Dominion Way, Worthing, UK.
- Heath MD Allergy Therapeutics (UK) Ltd, Dominion Way, Worthing, UK; Bencard Adjuvant Systems (a division of Allergy Therapeutics), Dominion Way, Worthing, UK. Electronic address: matthew.heath@allergytherapeutics.com.
- 2020-04-12
Published in:
- Trends in molecular medicine. - 2020
English
Since the discovery that IgE antibodies mediate allergy, decades of research have unraveled complex mechanisms associated with conventional immunotherapy and the vital protagonists that shape 'immune tolerance' to allergens. Debate exists on what should constitute the dominant effector mechanism in driving rational drug designs for next-generation immunotherapies. As vaccine technology continues to advance, the development of novel vaccines in this area of continued medical need might stand on a threshold of breakthrough inspired by experiments by Dunbar on the passive vaccination of allergic animals more than 100 years ago. In this opinion article, we discuss both novel insights into IgG antibodies as the principle effector modality induced by specific immunotherapy and advances in antigen-carrier design that may catapult allergy treatment into our modern world.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1016/j.molmed.2020.01.007
- PMID 32277930
- Persistent URL
- https://sonar.ch/global/documents/284558
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