Journal article
Enantioseparation of 1-phenyl-1-propanol by supercritical fluid-simulated moving bed chromatography.
- Rajendran A ETH Swiss Federal Institute of Technology Zurich, Institute of Process Engineering, ETH-Zentrum, ML G25, Sonneggstrasse 3, CH-8092 Zürich, Switzerland.
- Peper S
- Johannsen M
- Mazzotti M
- Morbidelli M
- Brunner G
- 2005-09-29
Published in:
- Journal of chromatography. A. - 2005
English
The enantioseparation of 1-phenyl-1-propanol through the supercritical fluid-simulated moving bed (SF-SMB) process is studied. Non-linear isotherms were measured on an analytical column, and used together with the triangle theory for SMB design to select operating conditions for the SF-SMB. Experiments were carried out on a pilot-scale SF-SMB plant at conditions that corresponded to the non-linear range of the isotherm. Under conditions of low feed concentration, complete separation (extract purity = 99.5%; raffinate purity = 98.4%) was achieved. Under conditions of larger feed concentration, the best separation corresponded to an extract purity of 98.0% and a raffinate purity of 94.0%, and yielded a productivity of 110 g of racemate per kg stationary phase per day.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.chroma.2005.02.040
- PMID 16188560
- Persistent URL
- https://sonar.ch/global/documents/284785
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