Elevated serum levels of TNF soluble receptors in patients with positive anti-neutrophil cytoplasmic antibodies.
- Roux-Lombard P Department of Medicine, University Hospital, Geneva, Switzerland.
- Lin HC
- Peter JB
- Dayer JM
- 1994-05-01
Published in:
- British journal of rheumatology. - 1994
Analysis of Variance
Antibodies, Antineutrophil Cytoplasmic
Autoantibodies
Biomarkers
Enzyme-Linked Immunosorbent Assay
Humans
Interleukin-8
Receptors, Tumor Necrosis Factor
Tumor Necrosis Factor-alpha
English
ANCA are found in various systemic vasculitis and are supposed to play a role in the pathogenesis of the disease, in co-operation with other factors such as cytokines. A total of 36 ANCA-positive and 10 ANCA-negative serum samples were analysed for the presence of TNF soluble receptors (TNF-sR), which are shed from the surface of activated cells and may act as TNF inhibitors. Of the ANCA-positive samples, 67% had elevated TNF-sR75 and 72% had elevated TNF-sR55 compared to ANCA-negative specimens (mean [S.E.] 18.7 [17.3] vs 3.6 [1.5] and 10.5 [9.7] vs 1.9 [0.7] ng/ml, P < 0.01). Elevation of TNF-sR in patients with ANCA suggests that cytokines and their inhibitors are involved in the pathogenesis of ANCA-associated autoimmune diseases.
- Language
-
- English
- Open access status
- green
- Identifiers
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- DOI 10.1093/rheumatology/33.5.428
- PMID 8173845
- Persistent URL
- https://sonar.ch/global/documents/285023
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