Occult Pathologic Findings in Reduction Mammaplasty in 5781 Patients-An International Multicenter Study.

Kuehlmann B; Vogl FD; Kempny T; Djedovic G; Huemer GM; Hüttinger P; Tinhofer IE; Hüttinger N; Steinstraesser L; Riml S; Waldner M; Bonham CA; Schenck TL; Wechselberger G; Haslik W; Koch H; Mandal P; Rab M; Pallua N; Prantl L; Larcher L

doi:10.3390/jcm9072223

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Journal article

Occult Pathologic Findings in Reduction Mammaplasty in 5781 Patients-An International Multicenter Study.

Kuehlmann B Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University, Stanford, CA 94305, USA.
Vogl FD Breast Health Center, General Hospital Merano, SABES South Tyrol, 39012 Meran, Italy.
Kempny T Division of Plastic and Reconstructive Surgery, Department of Surgery, Klinikum Wels-Grieskirchen, 4600 Wels-Grieskirchen, Austria.
Djedovic G Department of Plastic, Reconstructive and Aesthetic Surgery, Innsbruck Medical University, 6020 Innsbruck, Austria.
Huemer GM Section of Plastic Surgery, Kepler University Hospital, 4020 Linz, Austria.
Hüttinger P Department of Plastic, Reconstructive and Aesthetic Surgery, University Hospital St. Poelten, 3100 St. Poelten, Austria.
Tinhofer IE Department of Plastic, Aesthetic and Reconstructive Surgery, Wilhelminen Hospital, 1160 Vienna, Austria.
Hüttinger N Department of Plastic and Reconstructive Surgery, Medical Institution Rudolfstiftung, 1030 Vienna, Austria.
Steinstraesser L Department of Plastic, Reconstructive and Aesthetic Surgery, European Medical School at the Carl von Ossietzky University of Oldenburg, Evangelisches Krankenhaus, 26122 Oldenburg, Germany.
Riml S Academic Teaching Hospital Feldkirch, 6800 Feldkirch, Austria.
Waldner M Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland.
Bonham CA Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University, Stanford, CA 94305, USA.
Schenck TL Department for Hand, Plastic and Aesthetic Surgery, Ludwig-Maximilians University Munich, 80336 Munich, Germany.
Wechselberger G Department of Plastic, Aesthetic and Reconstructive Surgery, Hospital of the Barmherzige Brueder, Paracelsus Medical University Salzburg, 5020 Salzburg, Austria.
Haslik W Division of Plastic and Reconstructive Surgery, Medical University Vienna, 1090 Vienna, Austria.
Koch H Clinic for Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, 8036 Graz, Austria.
Mandal P Klinikum Nuernberg, Department of Plastic-, Reconstructive-, and Hand Surgery, Center for Burn Injuries, Paracelsus Medical University, 90471 Nuremberg, Germany.
Rab M Klinikum Klagenfurt am Woerthersee, Department of Plastic, Aesthetic and Reconstructive Surgery, 9020 Klagenfurt am Woerthersee, Austria.
Pallua N Department of Plastic Surgery, Hand Surgery, Burn Center, University Hospital Aachen, 52074 Aachen, Germany.
Prantl L University Center for Plastic, Reconstructive, Aesthetic and Hand Surgery, University Hospital Regensburg and Caritas Hospital St. Josef, 93053 Regensburg, Germany.
Larcher L Unit of Plastic Surgery, SABES, South Tyrol, 39042 Brixen, Italy.

2020-07-17

Published in:

Journal of clinical medicine. - 2020

international multicenter study

English Breast cancer is among the most commonly diagnosed cancers in the world, affecting one in eight women in their lifetimes. The disease places a substantial burden on healthcare systems in developed countries and often requires surgical correction. In spite of this, much of the breast cancer pathophysiology remains unknown, allowing for the cancer to develop to later stages prior to detection. Many women undergo reduction mammaplasties (RM) to adjust breast size, with over 500,000 operations being performed annually. Tissue samples from such procedures have drawn interest recently, with studies attempting to garner a better understanding of breast cancer's development. A number of samples have revealed nascent cancer developments that were previously undetected and unexpected. Investigating these so-called "occult" findings of cancer in otherwise healthy patients may provide further insight regarding risk factors and countermeasures. Here, we detail occult findings of cancer in reduction mammaplasty samples provided from a cohort of over 5000 patients from 16 different institutions in Europe. Although the majority of our resected breast tissue specimens were benign, our findings indicate that there is a continued need for histopathological examination. As a result, our study suggests that preoperative imaging should be routinely performed in patients scheduled for RM, especially those with risk factors of breast cancer, to identify and enable a primary oncologic approach.

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