Newcomers in the process of mitochondrial permeabilization.
- Lucken-Ardjomande S Department of Cell Biology, University of Geneva, 30 Quai Ernest-Ansermet, 1211 Geneva 4, Switzerland.
- Martinou JC
- 2005-01-28
Published in:
- Journal of cell science. - 2005
Animals
Apoptosis
Cardiolipins
Humans
Ion Channels
Membrane Lipids
Membrane Proteins
Mitochondria
Mitochondrial Membrane Transport Proteins
Models, Biological
Models, Molecular
Permeability
Porins
Proto-Oncogene Proteins c-bcl-2
Voltage-Dependent Anion Channels
bcl-2 Homologous Antagonist-Killer Protein
bcl-2-Associated X Protein
English
Under stress conditions, apoptogenic factors normally sequestered in the mitochondrial intermembrane space are released into the cytosol, caspases are activated and cells die by apoptosis. Although the precise mechanism that leads to the permeabilization of mitochondria is still unclear, the activation of multidomain pro-apoptotic proteins of the Bcl-2 family, such as Bax and Bak, is evidently crucial. Regulation of Bax and Bak by other members of the family has been known for a long time, but recent evidence suggests that additional unrelated proteins participate in the process, both as inhibitors and activators. The important rearrangements mitochondrial lipids undergo during apoptosis play a role in the permeabilization process and this role is probably more central than first envisioned.
- Language
-
- English
- Open access status
- hybrid
- Identifiers
-
- DOI 10.1242/jcs.01654
- PMID 15673686
- Persistent URL
- https://sonar.ch/global/documents/285455
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