Tuberculosis after initiation of antiretroviral therapy in low-income and high-income countries.
- Brinkhof MW
- Egger M
- Boulle A
- May M
- Hosseinipour M
- Sprinz E
- Braitstein P
- Dabis F
- Reiss P
- Bangsberg DR
- Rickenbach M
- Miro JM
- Myer L
- Mocroft A
- Nash D
- Keiser O
- Pascoe M
- van der Borght S
- Schechter M
- 2007-11-09
Published in:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. - 2007
Adult
Anti-Retroviral Agents
CD4 Lymphocyte Count
Developed Countries
Developing Countries
Female
HIV Infections
Humans
Incidence
Income
Male
Middle Aged
Risk Factors
Tuberculosis
English
We examined the incidence of and risk factors for tuberculosis during the first year of highly active antiretroviral therapy in low-income (4540 patients) and high-income (22,217 patients) countries. Although incidence was much higher in low-income countries, the reduction in the incidence of tuberculosis associated with highly active antiretroviral therapy was similar: the rate ratio for months 7-12 versus months 1-3 was 0.48 (95% confidence interval, 0.36-0.64) in low-income countries and 0.36 (95% confidence interval, 0.26-0.50) in high-income countries. A low CD4 cell count at the start of therapy was the most important risk factor in both settings.
- Language
-
- English
- Open access status
- bronze
- Identifiers
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- DOI 10.1086/522986
- PMID 17990236
- Persistent URL
- https://sonar.ch/global/documents/286174
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