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Metal-containing peptide nucleic acid conjugates.

  • Gasser G Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland. gilles.gasser@aci.unizh.ch
  • Sosniak AM
  • Metzler-Nolte N
  • 2011-05-05
Published in:
  • Dalton transactions (Cambridge, England : 2003). - 2011
Animals
Biomimetic Materials
Biosensing Techniques
Catalysis
Cell Membrane Permeability
Coordination Complexes
Cross-Linking Reagents
DNA
Deoxyribonucleases
Humans
Models, Molecular
Oxidation-Reduction
Peptide Hydrolases
Peptide Nucleic Acids
Ribonucleases
English Peptide Nucleic Acids (PNAs) are non-natural DNA/RNA analogues with favourable physico-chemical properties and promising applications. Discovered nearly 20 years ago, PNAs have recently re-gained quite a lot of attention. In this Perspective article, we discuss the latest advances on the preparation and utilisation of PNA monomers and oligomers containing metal complexes. These metal- conjugates have found applications in various research fields such as in the sequence-specific detection of nucleic acids, in the hydrolysis of nucleic acids and peptides, as radioactive probes or as modulators of PNA·DNA hybrid stability, and last but not least as probes for molecular and cell biology.
Language
  • English
Open access status
green
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https://sonar.ch/global/documents/286958
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