Live Long and Prosper for Antigen Cross-Presentation.
Münz CViral Immunobiology, Institute of Experimental Immunology, University of Zurich, 8057 Zurich, Switzerland. Electronic address: christian.muenz@uzh.ch.
English
Even though proteolytic antigen fragments are displayed for cross-presentation, rapid proteolysis of endocytosed antigens inhibits this process. In this issue of Immunity, Alloatti et al. (2015) describe how maturing dendritic cells keep phagosomes and lysosomes apart to ensure extended antigen life that leads to prosperous cross-presentation.