Journal article
Increased food diversity in the first year of life is inversely associated with allergic diseases.
- Roduit C University of Zurich, Children's Hospital, and Christine Kühne-Center for Allergy Research and Education, Zurich, Switzerland. Electronic address: Caroline.Roduit@kispi.uzh.ch.
- Frei R Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich and Christine Kühne-Center for Allergy Research and Education, Zurich, Switzerland.
- Depner M Dr von Hauner Children's Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
- Schaub B Dr von Hauner Children's Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
- Loss G Swiss Tropical and Public Health Institute and the University of Basel, Basel, Switzerland.
- Genuneit J Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
- Pfefferle P Institute for Laboratory Medicine, Pathobiochemistry and Molecular Diagnostics, Philipps University of Marburg, Marburg, Germany.
- Hyvärinen A Department of Environment Health, National Institute for Health and Welfare, Kuopio, Finland.
- Karvonen AM Department of Environment Health, National Institute for Health and Welfare, Kuopio, Finland.
- Riedler J Children's Hospital Schwarzach, Schwarzach, Austria.
- Dalphin JC Department of Respiratory Disease, UMR/CNRS 6249 Chrono-environment, University Hospital of Besançon, Besançon, France.
- Pekkanen J Department of Environment Health, National Institute for Health and Welfare, Kuopio, Finland.
- von Mutius E Dr von Hauner Children's Hospital, Ludwig-Maximilians-Universität, Munich, Germany.
- Braun-Fahrländer C Swiss Tropical and Public Health Institute and the University of Basel, Basel, Switzerland; University of Basel, Basel, Switzerland.
- Lauener R Children's Hospital of Eastern Switzerland St Gallen and the Christine Kühne-Center for Allergy Research and Education, Davos, Switzerland.
- 2014-02-11
Published in:
- The Journal of allergy and clinical immunology. - 2014
Asthma
children
food allergy and sensitization
food diversity
Age Factors
Child
Child, Preschool
Europe
Female
Gene Expression Regulation
Humans
Hypersensitivity
Immunoglobulin Class Switching
Immunoglobulin E
Infant
Infant Food
Infant, Newborn
Male
Prevalence
Prospective Studies
Risk Factors
T-Lymphocytes
English
BACKGROUND
The role of dietary factors in the development of allergies is a topic of debate, especially the potential associations between infant feeding practices and allergic diseases. Previously, we reported that increased food diversity introduced during the first year of life reduced the risk of atopic dermatitis.
OBJECTIVE
In this study we investigated the association between the introduction of food during the first year of life and the development of asthma, allergic rhinitis, food allergy, or atopic sensitization, taking precautions to address reverse causality. We further analyzed the association between food diversity and gene expression of T-cell markers and of Cε germline transcript, reflecting antibody isotype switching to IgE, measured at 6 years of age.
METHODS
Eight hundred fifty-six children who participated in a birth cohort study, Protection Against Allergy Study in Rural Environments/EFRAIM, were included. Feeding practices were reported by parents in monthly diaries during the first year of life. Data on environmental factors and allergic diseases were collected from questionnaires administered from birth up to 6 years of age.
RESULTS
An increased diversity of complementary food introduced in the first year of life was inversely associated with asthma with a dose-response effect (adjusted odds ratio with each additional food item introduced, 0.74 [95% CI, 0.61-0.89]). A similar effect was observed for food allergy and food sensitization. Furthermore, increased food diversity was significantly associated with an increased expression of forkhead box protein 3 and a decreased expression of Cε germline transcript.
CONCLUSION
An increased diversity of food within the first year of life might have a protective effect on asthma, food allergy, and food sensitization and is associated with increased expression of a marker for regulatory T cells.
The role of dietary factors in the development of allergies is a topic of debate, especially the potential associations between infant feeding practices and allergic diseases. Previously, we reported that increased food diversity introduced during the first year of life reduced the risk of atopic dermatitis.
OBJECTIVE
In this study we investigated the association between the introduction of food during the first year of life and the development of asthma, allergic rhinitis, food allergy, or atopic sensitization, taking precautions to address reverse causality. We further analyzed the association between food diversity and gene expression of T-cell markers and of Cε germline transcript, reflecting antibody isotype switching to IgE, measured at 6 years of age.
METHODS
Eight hundred fifty-six children who participated in a birth cohort study, Protection Against Allergy Study in Rural Environments/EFRAIM, were included. Feeding practices were reported by parents in monthly diaries during the first year of life. Data on environmental factors and allergic diseases were collected from questionnaires administered from birth up to 6 years of age.
RESULTS
An increased diversity of complementary food introduced in the first year of life was inversely associated with asthma with a dose-response effect (adjusted odds ratio with each additional food item introduced, 0.74 [95% CI, 0.61-0.89]). A similar effect was observed for food allergy and food sensitization. Furthermore, increased food diversity was significantly associated with an increased expression of forkhead box protein 3 and a decreased expression of Cε germline transcript.
CONCLUSION
An increased diversity of food within the first year of life might have a protective effect on asthma, food allergy, and food sensitization and is associated with increased expression of a marker for regulatory T cells.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/j.jaci.2013.12.1044
- PMID 24508301
- Persistent URL
- https://sonar.ch/global/documents/287267
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