Journal article

POPULATION GENETICS. Genomic evidence for the Pleistocene and recent population history of Native Americans.

  • Raghavan M Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Steinrücken M Computer Science Division, University of California, Berkeley, CA 94720, USA.
  • Harris K Department of Mathematics, University of California, Berkeley, CA 94720, USA.
  • Schiffels S Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  • Rasmussen S Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Kemitorvet, Building 208, 2800 Kongens Lyngby, Denmark.
  • DeGiorgio M Departments of Biology and Statistics, Pennsylvania State University, 502 Wartik Laboratory, University Park, PA 16802, USA.
  • Albrechtsen A The Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
  • Valdiosera C Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Ávila-Arcos MC Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Malaspinas AS Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Eriksson A Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
  • Moltke I The Bioinformatics Centre, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.
  • Metspalu M Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia.
  • Homburger JR Department of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, California 94305, USA.
  • Wall J Institute for Human Genetics, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA.
  • Cornejo OE School of Biological Sciences, Washington State University, PO Box 644236, Heald 429, Pullman, Washington 99164, USA.
  • Moreno-Mayar JV Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Korneliussen TS Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Pierre T Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Rasmussen M Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Campos PF Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • de Barros Damgaard P Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Allentoft ME Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Lindo J Department of Anthropology, University of Illinois at Urbana-Champaign, 607 S. Mathews Ave, Urbana, IL 61801, USA.
  • Metspalu E Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia.
  • Rodríguez-Varela R Centro Mixto, Universidad Complutense de Madrid-Instituto de Salud Carlos III de Evolución y Comportamiento Humano, Madrid, Spain.
  • Mansilla J Instituto Nacional de Antropología e Historia, Moneda 13, Centro, Cuauhtémoc, 06060 Mexico Mexico City, Mexico.
  • Henrickson C University of Utah, Department of Anthropology, 270 S 1400 E, Salt Lake City, Utah 84112, USA.
  • Seguin-Orlando A Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Malmström H Department of Evolutionary Biology and Science for Life Laboratory, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden.
  • Stafford T Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Shringarpure SS Department of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, California 94305, USA.
  • Moreno-Estrada A Department of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, California 94305, USA.
  • Karmin M Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia.
  • Tambets K Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia.
  • Bergström A Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  • Xue Y Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  • Warmuth V UCL Genetics Institute, Gower Street, London WC1E 6BT, UK.
  • Friend AD Department of Geography, University of Cambridge, Downing Place, Cambridge CB2 3EN, UK.
  • Singarayer J Centre for Past Climate Change and Department of Meteorology, University of Reading, Earley Gate, PO Box 243, Reading, UK.
  • Valdes P School of Geographical Sciences, University Road, Clifton, Bristol BS8 1SS, UK.
  • Balloux F UCL Genetics Institute, Gower Street, London WC1E 6BT, UK.
  • Leboreiro I Instituto Nacional de Antropología e Historia, Moneda 13, Centro, Cuauhtémoc, 06060 Mexico Mexico City, Mexico.
  • Vera JL Escuela Nacional de AntropologÍa e Historia, Periférico Sur y Zapote s/n. Colonia Isidro Fabela, Tlalpan, Isidro Fabela, 14030 Mexico City, Mexico.
  • Rangel-Villalobos H Instituto de Investigación en Genética Molecular, Universidad de Guadalajara, Ocotlán, Mexico.
  • Pettener D Dipartimento di Scienze Biologiche, Geologiche e Ambientali (BiGeA), Università di Bologna, Via Selmi 3, 40126 Bologna, Italy.
  • Luiselli D Dipartimento di Scienze Biologiche, Geologiche e Ambientali (BiGeA), Università di Bologna, Via Selmi 3, 40126 Bologna, Italy.
  • Davis LG Department of Anthropology, Oregon State University, 238 Waldo Hall, Corvallis, OR, 97331 USA.
  • Heyer E Museum National d'Histoire Naturelle, CNRS, Université Paris 7 Diderot, Sorbonne Paris Cité, Sorbonne Universités, Unité Eco-Anthropologie et Ethnobiologie (UMR7206), Paris, France.
  • Zollikofer CPE Anthropological Institute and Museum, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
  • Ponce de León MS Anthropological Institute and Museum, University of Zürich, Winterthurerstrasse 190, 8057 Zürich, Switzerland.
  • Smith CI Department of Archaeology and History, La Trobe University, Melbourne, Victoria 3086, Australia.
  • Grimes V Department of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, A1C 5S7, Canada.
  • Pike KA Department of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, A1C 5S7, Canada.
  • Deal M Department of Archaeology, Memorial University, Queen's College, 210 Prince Philip Drive, St. John's, Newfoundland, A1C 5S7, Canada.
  • Fuller BT Department of Earth System Science, University of California, Irvine, Keck CCAMS Group, B321 Croul Hall, Irvine, California, 92697, USA.
  • Arriaza B Instituto de Alta Investigación, Universidad de Tarapacá, 18 de Septiembre 2222, Carsilla 6-D Arica, Chile.
  • Standen V Departamento de Antropologia, Universidad de Tarapacá, 18 de Septiembre 2222. Casilla 6-D Arica, Chile.
  • Luz MF Fundação Museu do Homem Americano, Centro Cultural Sérgio Motta, Campestre, 64770-000 Sao Raimundo Nonato, Brazil.
  • Ricaut F Laboratoire d'Anthropologie Moléculaire et Imagérie de Synthèse UMR-5288, CNRS, Université de Toulouse, 31073 Toulouse, France.
  • Guidon N Fundação Museu do Homem Americano, Centro Cultural Sérgio Motta, Campestre, 64770-000 Sao Raimundo Nonato, Brazil.
  • Osipova L Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, 630090 Novosibirsk, Russia.
  • Voevoda MI Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, 630090 Novosibirsk, Russia.
  • Posukh OL Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Prospekt Lavrentyeva 10, 630090 Novosibirsk, Russia.
  • Balanovsky O Vavilov Institute of General Genetics, Gubkina 3, 119333 Moscow, Russia.
  • Lavryashina M Kemerovo State University, Krasnaya 3, 650000 Kemerovo, Russia.
  • Bogunov Y Vavilov Institute of General Genetics, Gubkina 3, 119333 Moscow, Russia.
  • Khusnutdinova E Institute of Biochemistry and Genetics, Ufa Scientific Center of RAS, Prospekt Oktyabrya 71, 450054 Ufa, Russia.
  • Gubina M Fundação Museu do Homem Americano, Centro Cultural Sérgio Motta, Campestre, 64770-000 Sao Raimundo Nonato, Brazil.
  • Balanovska E Research Centre for Medical Genetics, Moskvorechie 1, 115478 Moscow, Russia.
  • Fedorova S Department of Molecular Genetics, Yakut Scientific Centre of Complex Medical Problems, Sergelyahskoe Shosse 4, 677010 Yakutsk, Russia.
  • Litvinov S Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia.
  • Malyarchuk B Institute of Biological Problems of the North, Russian Academy of Sciences, Portovaya Street 18, Magadan 685000, Russia.
  • Derenko M Institute of Biological Problems of the North, Russian Academy of Sciences, Portovaya Street 18, Magadan 685000, Russia.
  • Mosher MJ Department of Anthropology, Western Washington University, Bellingham Washington 98225, USA.
  • Archer D Department of Anthropology, Northwest Community College, 353 Fifth Street, Prince Rupert, British Columbia V8J 3L6, Canada.
  • Cybulski J Canadian Museum of History, 100 Rue Laurier, Gatineau, Quebec K1A 0M8, Canada.
  • Petzelt B Metlakatla Treaty Office, PO Box 224, Prince Rupert, BC, Canada V8J 3P6.
  • Mitchell J Metlakatla Treaty Office, PO Box 224, Prince Rupert, BC, Canada V8J 3P6.
  • Worl R Sealaska Heritage Institute, 105 S. Seward Street, Juneau, Alaska 99801, USA.
  • Norman PJ Department of Structural Biology, Stanford University School of Medicine, D100 Fairchild Science Building, Stanford, California 94305-5126, USA.
  • Parham P Department of Structural Biology, Stanford University School of Medicine, D100 Fairchild Science Building, Stanford, California 94305-5126, USA.
  • Kemp BM School of Biological Sciences, Washington State University, PO Box 644236, Heald 429, Pullman, Washington 99164, USA.
  • Kivisild T Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia.
  • Tyler-Smith C Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  • Sandhu MS Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  • Crawford M Laboratory of Biological Anthropology, University of Kansas, 1415 Jayhawk Blvd., 622 Fraser Hall, Lawrence, Kansas 66045, USA.
  • Villems R Estonian Biocentre, Evolutionary Biology Group, Tartu 51010, Estonia.
  • Smith DG Molecular Anthropology Laboratory, 209 Young Hall, Department of Anthropology, University of California, One Shields Avenue, Davis, California 95616, USA.
  • Waters MR Center for the Study of the First Americans, Texas A&M University, College Station, Texas 77843-4352, USA.
  • Goebel T Center for the Study of the First Americans, Texas A&M University, College Station, Texas 77843-4352, USA.
  • Johnson JR Santa Barbara Museum of Natural History, 2559 Puesta del Sol, Santa Barbara, CA 93105, USA.
  • Malhi RS Department of Anthropology, University of Illinois at Urbana-Champaign, 607 S. Mathews Ave, Urbana, IL 61801, USA.
  • Jakobsson M Department of Evolutionary Biology and Science for Life Laboratory, Uppsala University, Norbyvägen 18D, SE-752 36 Uppsala, Sweden.
  • Meltzer DJ Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
  • Manica A Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
  • Durbin R Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK.
  • Bustamante CD Department of Genetics, School of Medicine, Stanford University, 300 Pasteur Dr. Lane Bldg Room L331, Stanford, California 94305, USA.
  • Song YS Computer Science Division, University of California, Berkeley, CA 94720, USA.
  • Nielsen R Department of Integrative Biology, University of California, 3060 Valley Life Sciences Bldg #3140, Berkeley, CA 94720, USA.
  • Willerslev E Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5-7, 1350 Copenhagen, Denmark.
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  • 2015-07-23
Published in:
  • Science (New York, N.Y.). - 2015
English How and when the Americas were populated remains contentious. Using ancient and modern genome-wide data, we found that the ancestors of all present-day Native Americans, including Athabascans and Amerindians, entered the Americas as a single migration wave from Siberia no earlier than 23 thousand years ago (ka) and after no more than an 8000-year isolation period in Beringia. After their arrival to the Americas, ancestral Native Americans diversified into two basal genetic branches around 13 ka, one that is now dispersed across North and South America and the other restricted to North America. Subsequent gene flow resulted in some Native Americans sharing ancestry with present-day East Asians (including Siberians) and, more distantly, Australo-Melanesians. Putative "Paleoamerican" relict populations, including the historical Mexican Pericúes and South American Fuego-Patagonians, are not directly related to modern Australo-Melanesians as suggested by the Paleoamerican Model.
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