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Tissue repair brakes: A common paradigm in the biology of regeneration.

  • Cigliola V Department of Cell Biology, Regeneration Next, Duke University Medical Center, Durham, North Carolina.
  • Ghila L Department of Clinical Science, University of Bergen, Bergen, Norway.
  • Chera S Department of Clinical Science, University of Bergen, Bergen, Norway.
  • Herrera PL Department of Genetic Medicine & Development, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • 2019-11-14
Published in:
  • Stem cells (Dayton, Ohio). - 2020
liver regeneration
pancreas
plasticity
proliferation, reprogramming, transdifferentiation
English To date, most attention on tissue regeneration has focused on the exploration of positive cues promoting or allowing the engagement of natural cellular restoration upon injury. In contrast, the signals fostering cell identity maintenance in the vertebrate body have been poorly investigated; yet they are crucial, for their counteraction could become a powerful method to induce and modulate regeneration. Here we review the mechanisms inhibiting pro-regenerative spontaneous adaptive cell responses in different model organisms and organs. The pharmacological or genetic/epigenetic modulation of such regenerative brakes could release a dormant but innate adaptive competence of certain cell types and therefore boost tissue regeneration in different situations.
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  • English
Open access status
bronze
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https://sonar.ch/global/documents/287891
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