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Mitogenesis and protein synthesis: a role for ribosomal protein S6 phosphorylation?
Journal article

Mitogenesis and protein synthesis: a role for ribosomal protein S6 phosphorylation?

  • 1994-11-01
Published in:
  • BioEssays : news and reviews in molecular, cellular and developmental biology. - 1994
Amino Acid Sequence
Animals
Drosophila melanogaster
Fungal Proteins
Gene Expression Regulation
Humans
Mice
Molecular Sequence Data
Phosphorylation
Protein Biosynthesis
Protein Processing, Post-Translational
RNA, Messenger
Rats
Ribosomal Protein S6
Ribosomal Proteins
Ribosomes
Saccharomyces cerevisiae
Sequence Alignment
Sequence Homology, Amino Acid
Species Specificity
English It has been known for 20 years that the ribosomal protein S6 is rapidly phosphorylated when cells are stimulated to grow or divide. Furthermore, numerous studies have documented that there is a strong correlation between increases in S6 phosphorylation and protein synthesis, leading to the idea that S6 phosphorylation is involved in up-regulating translation. In an attempt to define a mechanism by which S6 phosphorylation exerts translational control, other studies have focused on characterizing the sites of phosphorylation of this protein and its location within the ribosome. Recent data show that S6 is a protein which may have diverse cellular functions and is essential for normal development, and that it may be involved in the translational regulation of a specific class of messages.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/287922
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