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B cell development and its deregulation to transformed states at the pre-B cell receptor-expressing pre-BII cell stage.
Journal article

B cell development and its deregulation to transformed states at the pre-B cell receptor-expressing pre-BII cell stage.

  • Melchers F Department of Cell Biology, Biozentrum of the University of Basel, Switzerland. fritz.melchers@unibas.ch
  • 2005-12-06
Published in:
  • Current topics in microbiology and immunology. - 2005
Animals
Apoptosis
B-Lymphocytes
Cell Differentiation
Cell Proliferation
Cell Transformation, Neoplastic
Gene Rearrangement, B-Lymphocyte
Humans
Interleukin-7
Lymphoma, B-Cell
Mice
Mutation
PAX5 Transcription Factor
Receptors, Antigen, B-Cell
Receptors, Interleukin-7
Signal Transduction
English This chapter will review the scenario of normal B cell development--from the decision of a lymphoid progenitor to enter the B-lineage, over the stages of the generation of the repertoires of antigen-receptor (immunoglobulin)-expressing cells, to the response of mature B cells to develop memory and plasma cells--highlighting some of the cellular stages and the molecular mechanisms that can generate and select transformed states of cells. The scenarios for pre-B lymphoma (lymphocytic leukaemia) development are discussed in more detail.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/288258
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