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The cellular and biochemical rules of lipid antigen presentation.
Journal article

The cellular and biochemical rules of lipid antigen presentation.

  • De Libero G Experimental Immunology, Department of Biomedicine, University Hospital Basel, 4031 Basel, Switzerland. gennaro.delibero@unibas.ch
  • Collmann A
  • Mori L
  • 2009-09-04
Published in:
  • European journal of immunology. - 2009
Animals
Antigen Presentation
Antigens
Antigens, CD1
Bacterial Infections
Biological Transport
Humans
Lipid Metabolism
Lipids
Models, Immunological
English The recognition of both protein and lipid antigens follows similar strategies that rely on different molecular mechanisms. APC present lipid antigens exploiting the same mechanisms implicated in lipid translocation, lipoprotein assembly and lipid degradation. An important issue is how the lipid structure contributes to antigenicity. Lipid hydrophobicity influences the modes of internalization by APC, the trafficking through different membrane compartments, the binding to CD1 molecules and the stability of antigenic complexes. Some glycolipids with large hydrophilic parts require processing of the sugar moieties exerted by lysosomal hydrolases. Finally, extraction of lipids from membranes, their solubilization and loading on CD1 molecules are facilitated by the same lysosomal lipid-binding proteins that are also instrumental in lipid catabolism. More recent investigations reveal how lipid-specific immunity is regulated during infections. In this review we describe the main cellular and biochemical rules of lipid antigen presentation and discuss their implications in anti-microbial and autoimmune responses.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/288423
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