Journal article
S-nitrosylation of proteins.
- Broillet MC Institut de Pharmacologie et de Toxicologie, Université de Lausanne, Switzerland. marie-christine.broillet@ipharm.unil.ch
- 1999-08-12
Published in:
- Cellular and molecular life sciences : CMLS. - 1999
Animals
Apoptosis
Arginine
Cyclic GMP
Cysteine
HIV Protease
Hemoglobins
Humans
Immune System
Ion Transport
Macrophages
Nitric Oxide
Nitroso Compounds
Oxidation-Reduction
Platelet Aggregation
Protein Processing, Post-Translational
Signal Transduction
English
The transfer of a nitric oxide group to cysteine sulfhydryls on proteins, known as S-nitrosylation, is increasingly becoming recognized as a ubiquitous regulatory reaction comparable to phosphorylation. It represents a form of redox modulation in diverse tissues, including the brain. An increasing number of proteins have been found to undergo S-nitrosylation in vivo. These proteins are called S-nitrosothiols, and may play an important role in many processes ranging from signal transduction, DNA repair, host defense, and blood pressure control to ion channel regulation and neurotransmission. This review focuses on the importance of the S-nitrosylation reaction and describes some recently identified S-nitrosothiols in various fields of research.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1007/s000180050354
- PMID 10442087
- Persistent URL
- https://sonar.ch/global/documents/289259
Statistics
Document views: 56
File downloads: