Journal article
BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF.
- Thompson JS Biogen, 12 Cambridge Center, Cambridge, MA 02142, USA., The Institute of Biochemistry, University of Lausanne, CH-1066, Epalinges, Switzerland.
- Bixler SA
- Qian F
- Vora K
- Scott ML
- Cachero TG
- Hession C
- Schneider P
- Sizing ID
- Mullen C
- Strauch K
- Zafari M
- Benjamin CD
- Tschopp J
- Browning JL
- Ambrose C
- 2001-08-18
Published in:
- Science (New York, N.Y.). - 2001
Amino Acid Sequence
Animals
B-Cell Activating Factor
B-Cell Activation Factor Receptor
B-Cell Maturation Antigen
B-Lymphocytes
Cell Line
Chromosome Mapping
Chromosomes, Human, Pair 22
Cloning, Molecular
Homeostasis
Humans
Ligands
Lymphoid Tissue
Male
Membrane Proteins
Mice
Mice, Inbred A
Mice, Inbred C57BL
Molecular Sequence Data
RNA, Messenger
Receptors, Tumor Necrosis Factor
Recombinant Fusion Proteins
Signal Transduction
Transfection
Transmembrane Activator and CAML Interactor Protein
Tumor Necrosis Factor-alpha
English
B cell homeostasis has been shown to critically depend on BAFF, the B cell activation factor from the tumor necrosis factor (TNF) family. Although BAFF is already known to bind two receptors, BCMA and TACI, we have identified a third receptor for BAFF that we have termed BAFF-R. BAFF-R binding appears to be highly specific for BAFF, suggesting a unique role for this ligand-receptor interaction. Consistent with this, the BAFF-R locus is disrupted in A/WySnJ mice, which display a B cell phenotype qualitatively similar to that of the BAFF-deficient mice. Thus, BAFF-R appears to be the principal receptor for BAFF-mediated mature B cell survival.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1126/science.1061965
- PMID 11509692
- Persistent URL
- https://sonar.ch/global/documents/289328
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