Lack of multiple copies of pfmdr1 gene in Papua New Guinea.
- Hodel EM Swiss Tropical Institute, Socinstrasse 57, P.O. Box 4002 Basle, Switzerland.
- Marfurt J
- Müller D
- Rippert A
- Borrmann S
- Müller I
- Reeder JC
- Siba P
- Genton B
- Beck HP
- 2008-07-05
Published in:
- Transactions of the Royal Society of Tropical Medicine and Hygiene. - 2008
Animals
Antimalarials
Artemisinins
Artesunate
Drug Resistance
Genes, MDR
Genotype
Humans
Malaria, Falciparum
Mefloquine
Multidrug Resistance-Associated Proteins
Papua New Guinea
Plasmodium falciparum
Polymorphism, Genetic
English
We describe here the results of an analysis of Plasmodium falciparum multidrug resistance protein 1 (pfmdr1) gene copy number from 440 field isolates from Papua New Guinea. No multiple copies of the gene were found, which corresponds to the lack of usage of mefloquine. These data extend regional knowledge about the distribution of multidrug-resistant P. falciparum.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1016/j.trstmh.2008.05.017
- PMID 18599099
- Persistent URL
- https://sonar.ch/global/documents/290781
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