Journal article
Dissecting the human immunologic memory for pathogens.
- Zielinski CE Institute for Research in Biomedicine, Bellinzona, Switzerland.
- Corti D
- Mele F
- Pinto D
- Lanzavecchia A
- Sallusto F
- 2011-02-26
Published in:
- Immunological reviews. - 2011
B-Lymphocytes
Drug Design
Host-Pathogen Interactions
Humans
Immunologic Memory
T-Lymphocytes
Vaccines
English
Studies on immunologic memory in animal models and especially in the human system are instrumental to identify mechanisms and correlates of protection necessary for vaccine development. In this article, we provide an overview of the cellular basis of immunologic memory. We also describe experimental approaches based on high throughput cell cultures, which we have developed to interrogate human memory T cells, B cells, and plasma cells. We discuss how these approaches can provide new tools and information for vaccine design, in a process that we define as 'analytic vaccinology'.
- Language
-
- English
- Open access status
- closed
- Identifiers
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- DOI 10.1111/j.1600-065X.2010.01000.x
- PMID 21349085
- Persistent URL
- https://sonar.ch/global/documents/292083
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