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New trends in molecular and cellular biomarker discovery for colorectal cancer.
Journal article

New trends in molecular and cellular biomarker discovery for colorectal cancer.

  • Aghagolzadeh P Parisa Aghagolzadeh, Ramin Radpour, Department of Clinical Research, University Hospital of Bern, 3010 Bern, Switzerland.
  • Radpour R Parisa Aghagolzadeh, Ramin Radpour, Department of Clinical Research, University Hospital of Bern, 3010 Bern, Switzerland.
  • 2016-07-20
Published in:
  • World journal of gastroenterology. - 2016
Biomarkers
Cancer diagnosis
Cancer therapy
Colorectal cancer
Predictive marker
Prognostic marker
Adenomatous Polyposis Coli Protein
Biomarkers, Tumor
Chromosomal Instability
Colorectal Neoplasms
DNA Methylation
DNA, Neoplasm
Feces
Humans
Inflammation
MicroRNAs
Mutation
Neoplastic Cells, Circulating
Neovascularization, Pathologic
Prognosis
Proto-Oncogene Proteins B-raf
Proto-Oncogene Proteins p21(ras)
Telomere
Transcriptome
Tumor Suppressor Protein p53
beta Catenin
English Colorectal cancer (CRC) is the third leading cause of cancer death worldwide, which is consequence of multistep tumorigenesis of several genetic and epigenetic events. Since CRC is mostly asymptomatic until it progresses to advanced stages, the early detection using effective screening approaches, selection of appropriate therapeutic strategies and efficient follow-up programs are essential to reduce CRC mortalities. Biomarker discovery for CRC based on the personalized genotype and clinical information could facilitate the classification of patients with certain types and stages of cancer to tailor preventive and therapeutic approaches. These cancer-related biomarkers should be highly sensitive and specific in a wide range of specimen(s) (including tumor tissues, patients' fluids or stool). Reliable biomarkers which enable the early detection of CRC, can improve early diagnosis, prognosis, treatment response prediction, and recurrence risk. Advances in our understanding of the natural history of CRC have led to the development of different CRC associated molecular and cellular biomarkers. This review highlights the new trends and approaches in CRC biomarker discovery, which could be potentially used for early diagnosis, development of new therapeutic approaches and follow-up of patients.
Language
  • English
Open access status
hybrid
Identifiers
Persistent URL
https://sonar.ch/global/documents/292552
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