Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment: a systematic review incorporating an indirect-comparisons meta-analysis.
- Hilfiker R School of Health Sciences, HES-SO Valais-Wallis, University of Applied Sciences and Arts Western Switzerland Valais, Leukerbad, Switzerland.
- Meichtry A Institute of Physiotherapy, Zurich University of Applied Sciences, Winterthur, Switzerland.
- Eicher M School of Health Sciences, University of Applied Sciences and Arts Western Switzerland, Fribourg, Switzerland.
- Nilsson Balfe L School of Health Sciences, HES-SO Valais-Wallis, University of Applied Sciences and Arts Western Switzerland Valais, Leukerbad, Switzerland.
- Knols RH Directory of Research and Education, Physiotherapy Occupational Therapy Research, Center University Hospital Zurich, Zurich, Switzerland.
- Verra ML Department of Physiotherapy, Inselspital, Bern University Hospital, Berne, Switzerland.
- Taeymans J Bern University of Applied Sciences Health, Berne, Switzerland.
- 2017-05-15
Published in:
- British journal of sports medicine. - 2018
cancer related fatigue
exercise
indirect comparison meta-analysis.
network meta-analysis
non-pharmaceutical interventions
Cognitive Behavioral Therapy
Exercise Therapy
Fatigue
Massage
Neoplasms
Randomized Controlled Trials as Topic
Relaxation Therapy
Resistance Training
Tai Ji
Yoga
English
AIM
To assess the relative effects of different types of exercise and other non-pharmaceutical interventions on cancer-related fatigue (CRF) in patients during and after cancer treatment.
DESIGN
Systematic review and indirect-comparisons meta-analysis.
DATA SOURCES
Articles were searched in PubMed, Cochrane CENTRAL and published meta-analyses.
ELIGIBILITY CRITERIA FOR SELECTING STUDIES
Randomised studies published up to January 2017 evaluating different types of exercise or other non-pharmaceutical interventions to reduce CRF in any cancer type during or after treatment.
STUDY APPRAISAL AND SYNTHESIS
Risk of bias assessment with PEDro criteria and random effects Bayesian network meta-analysis.
RESULTS
We included 245 studies. Comparing the treatments with usual care during cancer treatment, relaxation exercise was the highest ranked intervention with a standardisedmean difference (SMD) of -0.77 (95% Credible Interval (CrI) -1.22 to -0.31), while massage (-0.78; -1.55 to -0.01), cognitive-behavioural therapy combined with physical activity (combined CBT, -0.72; -1.34 to -0.09), combined aerobic and resistance training (-0.67; -1.01 to -0.34), resistance training (-0.53; -1.02 to -0.03), aerobic (-0.53; -0.80 to -0.26) and yoga (-0.51; -1.01 to 0.00) all had moderate-to-large SMDs. After cancer treatment, yoga showed the highest effect (-0.68; -0.93 to -0.43). Combined aerobic and resistance training (-0.50; -0.66 to -0.34), combined CBT (-0.45; -0.70 to -0.21), Tai-Chi (-0.45; -0.84 to -0.06), CBT (-0.42; -0.58 to -0.25), resistance training (-0.35; -0.62 to -0.08) and aerobic (-0.33; -0.51 to -0.16) showed all small-to-moderate SMDs.
CONCLUSIONS
Patients can choose among different effective types of exercise and non-pharmaceutical interventions to reduce CRF.
To assess the relative effects of different types of exercise and other non-pharmaceutical interventions on cancer-related fatigue (CRF) in patients during and after cancer treatment.
DESIGN
Systematic review and indirect-comparisons meta-analysis.
DATA SOURCES
Articles were searched in PubMed, Cochrane CENTRAL and published meta-analyses.
ELIGIBILITY CRITERIA FOR SELECTING STUDIES
Randomised studies published up to January 2017 evaluating different types of exercise or other non-pharmaceutical interventions to reduce CRF in any cancer type during or after treatment.
STUDY APPRAISAL AND SYNTHESIS
Risk of bias assessment with PEDro criteria and random effects Bayesian network meta-analysis.
RESULTS
We included 245 studies. Comparing the treatments with usual care during cancer treatment, relaxation exercise was the highest ranked intervention with a standardisedmean difference (SMD) of -0.77 (95% Credible Interval (CrI) -1.22 to -0.31), while massage (-0.78; -1.55 to -0.01), cognitive-behavioural therapy combined with physical activity (combined CBT, -0.72; -1.34 to -0.09), combined aerobic and resistance training (-0.67; -1.01 to -0.34), resistance training (-0.53; -1.02 to -0.03), aerobic (-0.53; -0.80 to -0.26) and yoga (-0.51; -1.01 to 0.00) all had moderate-to-large SMDs. After cancer treatment, yoga showed the highest effect (-0.68; -0.93 to -0.43). Combined aerobic and resistance training (-0.50; -0.66 to -0.34), combined CBT (-0.45; -0.70 to -0.21), Tai-Chi (-0.45; -0.84 to -0.06), CBT (-0.42; -0.58 to -0.25), resistance training (-0.35; -0.62 to -0.08) and aerobic (-0.33; -0.51 to -0.16) showed all small-to-moderate SMDs.
CONCLUSIONS
Patients can choose among different effective types of exercise and non-pharmaceutical interventions to reduce CRF.
- Language
-
- English
- Open access status
- hybrid
- Identifiers
-
- DOI 10.1136/bjsports-2016-096422
- PMID 28501804
- Persistent URL
- https://sonar.ch/global/documents/292568
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