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The Cellular Functions of Eosinophils: Collegium Internationale Allergologicum (CIA) Update 2020.

  • Simon HU Institute of Pharmacology, University of Bern, Bern, Switzerland, hus@pki.unibe.ch.
  • Yousefi S Institute of Pharmacology, University of Bern, Bern, Switzerland.
  • Germic N Institute of Pharmacology, University of Bern, Bern, Switzerland.
  • Arnold IC Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
  • Haczku A University of California, Davis, Davis, California, USA.
  • Karaulov AV Department of Clinical Immunology and Allergology, Sechenov University, Moscow, Russian Federation.
  • Simon D Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Rosenberg HF Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
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  • 2019-12-02
Published in:
  • International archives of allergy and immunology. - 2020
Asthma
Eosinophil cytolysis
Eosinophil degranulation
Eosinophil extracellular traps
Eosinophils
Hypereosinophilic syndromes
Inflammation
Interleukin-5
M2 macrophages
Major basic protein
Mast cells
Targeted therapy
Animals
Antibody Formation
Eosinophils
Humans
Hypereosinophilic Syndrome
Immunity, Cellular
Immunomodulation
Inflammation
Interleukin-5
Wound Healing
English Eosinophils and their secretory mediators play an important role in the pathogenesis of infectious and inflammatory disorders. Although eosinophils are largely evolutionally conserved, their physiologic functions are not well understood. Given the availability of new eosinophil-targeted depletion therapies, there has been a renewed interest in understanding eosinophil biology as these strategies may result in secondary disorders when applied over long periods of time. Recent data suggest that eosinophils are not only involved in immunological effector functions but also carry out tissue protective and immunoregulatory functions that actively contribute to the maintenance of homeostasis. Prolonged eosinophil depletion may therefore result in the development of secondary disorders. Here, we review recent literature pointing to important roles for eosinophils in promoting immune defense, antibody production, activation of adipose tissue, and tissue remodeling and fibrosis. We also reflect on patient data from clinical trials that feature anti-eosinophil therapeutics.
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  • English
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bronze
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https://sonar.ch/global/documents/293052
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