Back
Cathepsins: key modulators of cell death and inflammatory responses.
Journal article

Cathepsins: key modulators of cell death and inflammatory responses.

  • Conus S Institute of Pharmacology, University of Bern, Friedbühlstrasse 49, CH-3010 Bern, Switzerland.
  • Simon HU
  • 2008-09-03
Published in:
  • Biochemical pharmacology. - 2008
Animals
Cathepsins
Cell Death
Humans
Immune System
Inflammation
Mice
English Apoptosis is a key mechanism in the build up and maintenance of both innate and adaptive immunity as well as in the regulation of cellular homeostasis in almost every organ and tissue. Central to the apoptotic process is a family of intracellular cysteine proteases with aspartate-specificity, called caspases. Nevertheless, there is growing evidence that other non-caspase proteases, in particular lysosomal cathepsins, can play an important role in the regulation of apoptosis. In this review, the players and the molecular mechanisms involved in the lysosomal apoptotic pathways will be discussed as well as the importance of these pathways in the immune system and the pathogenesis of diseases.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/294085
Statistics
Document views: 70 File downloads: