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Online daily adaptive proton therapy.
Journal article

Online daily adaptive proton therapy.

  • Albertini F Paul Scherrer Institute, Center for Proton Therapy, Switzerland.
  • Matter M Paul Scherrer Institute, Center for Proton Therapy, Switzerland.
  • Nenoff L Paul Scherrer Institute, Center for Proton Therapy, Switzerland.
  • Zhang Y Paul Scherrer Institute, Center for Proton Therapy, Switzerland.
  • Lomax A Paul Scherrer Institute, Center for Proton Therapy, Switzerland.
  • 2019-10-25
Published in:
  • The British journal of radiology. - 2020
Humans
Neoplasms
Organs at Risk
Photons
Proton Therapy
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Conformal
Workflow
English It is recognized that the use of a single plan calculated on an image acquired some time before the treatment is generally insufficient to accurately represent the daily dose to the target and to the organs at risk. This is particularly true for protons, due to the physical finite range. Although this characteristic enables the generation of steep dose gradients, which is essential for highly conformal radiotherapy, it also tightens the dependency of the delivered dose to the range accuracy. In particular, the use of an outdated patient anatomy is one of the most significant sources of range inaccuracy, thus affecting the quality of the planned dose distribution. A plan should be ideally adapted as soon as anatomical variations occur, ideally online. In this review, we describe in detail the different steps of the adaptive workflow and discuss the challenges and corresponding state-of-the art developments in particular for an online adaptive strategy.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/295400
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