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Nuclear Lamins: Thin Filaments with Major Functions.
Journal article

Nuclear Lamins: Thin Filaments with Major Functions.

  • de Leeuw R Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
  • Gruenbaum Y Department of Genetics, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
  • Medalia O Department of Biochemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland; Department of Life Sciences and the National Institute for Biotechnology in the Negev, Ben-Gurion University, Beer-Sheva 84105, Israel. Electronic address: omedalia@bioc.uzh.cho.
  • 2017-09-13
Published in:
  • Trends in cell biology. - 2018
cryo-electron tomography
lamin-binding proteins
laminopathies
nuclear envelope
nuclear lamina
Animals
Chromatin
Cryoelectron Microscopy
Gene Expression Regulation
Humans
Intermediate Filaments
Lamins
Models, Molecular
Mutation
Nuclear Lamina
Nuclear Pore
English The nuclear lamina is a nuclear peripheral meshwork that is mainly composed of nuclear lamins, although a small fraction of lamins also localizes throughout the nucleoplasm. Lamins are classified as type V intermediate filament (IF) proteins. Mutations in lamin genes cause at least 15 distinct human diseases, collectively termed laminopathies, including muscle, metabolic, and neuronal diseases, and can cause accelerated aging. Most of these mutations are in the LMNA gene encoding A-type lamins. A growing number of nuclear proteins are known to bind lamins and are implicated in both nuclear and cytoskeletal organization, mechanical stability, chromatin organization, signaling, gene regulation, genome stability, and cell differentiation. Recent studies reveal the organization of the lamin filament meshwork in somatic cells where they assemble as tetramers in cross-section of the filaments.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/296838
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