T-cell exhaustion in HIV infection.
- Fenwick C Service of Immunology and Allergy, Department of Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
- Joo V Service of Immunology and Allergy, Department of Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
- Jacquier P Service of Immunology and Allergy, Department of Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
- Noto A Service of Immunology and Allergy, Department of Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
- Banga R Service of Immunology and Allergy, Department of Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
- Perreau M Service of Immunology and Allergy, Department of Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
- Pantaleo G Service of Immunology and Allergy, Department of Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
- 2019-12-29
Published in:
- Immunological reviews. - 2019
HIV
PD-1
T-cell exhaustion
chronic viral infection
immune checkpoint inhibitors
Anti-Retroviral Agents
Antigens, Viral
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Disease Progression
HIV Infections
HIV-1
Host-Pathogen Interactions
Humans
Lymphocyte Activation
English
The T-cell response is central in the adaptive immune-mediated elimination of pathogen-infected and/or cancer cells. This activated T-cell response can inflict an overwhelming degree of damage to the targeted cells, which in most instances leads to the control and elimination of foreign invaders. However, in conditions of chronic infection, persistent exposure of T cells to high levels of antigen results in a severe T-cell dysfunctional state called exhaustion. T-cell exhaustion leads to a suboptimal immune-mediated control of multiple viral infections including the human immunodeficiency virus (HIV). In this review, we will discuss the role of T-cell exhaustion in HIV disease progression, the long-term defect of T-cell function even in aviremic patients on antiretroviral therapy (ART), the role of exhaustion-specific markers in maintaining a reservoir of latently infected cells, and exploiting these markers in HIV cure strategies.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1111/imr.12823
- PMID 31883174
- Persistent URL
- https://sonar.ch/global/documents/29701
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