MDSCs in infectious diseases: regulation, roles, and readjustment.

Dorhoi A; Glaría E; Garcia-Tellez T; Nieuwenhuizen NE; Zelinskyy G; Favier B; Singh A; Ehrchen J; Gujer C; Münz C; Saraiva M; Sohrabi Y; Sousa AE; Delputte P; Müller-Trutwin M; Valledor AF

doi:10.1007/s00262-018-2277-y

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Journal article

MDSCs in infectious diseases: regulation, roles, and readjustment.

Dorhoi A Institute of Immunology, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493, Greifswald, Insel Riems, Germany. anca.dorhoi@fli.de.
Glaría E Nuclear Receptor Group, Department of Cell Biology, Physiology and Immunology, School of Biology, University of Barcelona, Av. Diagonal, 643, 3rd floor, 08028, Barcelona, Spain.
Garcia-Tellez T Institut Pasteur, HIV Inflammation and Persistence Unit, Paris, France.
Nieuwenhuizen NE Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.
Zelinskyy G Institute of Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Favier B Immunology of Viral Infections and Autoimmune Diseases (IMVA), IDMIT Department, CEA, Université Paris Sud 11, INSERM U1184, IBJF, Fontenay-aux-Roses, France.
Singh A University Children's Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen, Tübingen, Germany.
Ehrchen J Department of Dermatology, University Hospital Münster, Münster, Germany.
Gujer C Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zurich, Switzerland.
Münz C Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zurich, Switzerland.
Saraiva M i3S-Instituto de Investigação e Inovação em Saúde, Porto, Portugal.
Sohrabi Y Molecular and Translational Cardiology, Department of Cardiovascular Medicine, University Hospital Münster, Münster, Germany.
Sousa AE Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal.
Delputte P Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Antwerp, Belgium.
Müller-Trutwin M Institut Pasteur, HIV Inflammation and Persistence Unit, Paris, France.
Valledor AF Nuclear Receptor Group, Department of Cell Biology, Physiology and Immunology, School of Biology, University of Barcelona, Av. Diagonal, 643, 3rd floor, 08028, Barcelona, Spain. afernandezvalledor@ub.edu.

2018-12-21

Published in:

Cancer immunology, immunotherapy : CII. - 2019

Myeloid-Derived Suppressor Cells

English Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host.

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