COUP-TFI/Nr2f1 Orchestrates Intrinsic Neuronal Activity during Development of the Somatosensory Cortex

Del Pino, Isabel; Tocco, Chiara; Magrinelli, Elia; Marcantoni, Andrea; Ferraguto, Celeste; Tomagra, Giulia; Bertacchi, Michele; Alfano, Christian; Leinekugel, Xavier; Frick, Andreas; Studer, Michèle

doi:10.1093/cercor/bhaa137

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Journal article

COUP-TFI/Nr2f1 Orchestrates Intrinsic Neuronal Activity during Development of the Somatosensory Cortex

Del Pino, Isabel ORCID Centro de Investigación Príncipe Felipe, 46012 Valencia, Spain
Tocco, Chiara ORCID Université Côte d’Azur, CNRS, Inserm, iBV, 06108 Nice, France
Magrinelli, Elia ORCID Département des Neurosciences Fondamentales, Université de Lausanne, CH-1005 Lausanne, Switzerland
Marcantoni, Andrea ORCID Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, 10125 Torino, Italy
Ferraguto, Celeste Université Côte d’Azur, CNRS, Inserm, iBV, 06108 Nice, France
Tomagra, Giulia ORCID Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, 10125 Torino, Italy
Bertacchi, Michele ORCID Université Côte d’Azur, CNRS, Inserm, iBV, 06108 Nice, France
Alfano, Christian Université Côte d’Azur, CNRS, Inserm, iBV, 06108 Nice, France
Leinekugel, Xavier ORCID Université de Bordeaux, Inserm U1215, Neurocentre Magendie, 33077 Bordeaux, France
Frick, Andreas ORCID Université de Bordeaux, Inserm U1215, Neurocentre Magendie, 33077 Bordeaux, France
Studer, Michèle ORCID Université Côte d’Azur, CNRS, Inserm, iBV, 06108 Nice, France

2020-6-23

Published in:

Cerebral Cortex. - Oxford University Press (OUP). - 2020, vol. 30, no. 11, p. 5667-5685

Cognitive Neuroscience

Cellular and Molecular Neuroscience

English Abstract
The formation of functional cortical maps in the cerebral cortex results from a timely regulated interaction between intrinsic genetic mechanisms and electrical activity. To understand how transcriptional regulation influences network activity and neuronal excitability within the neocortex, we used mice deficient for Nr2f1 (also known as COUP-TFI), a key determinant of primary somatosensory (S1) area specification during development. We found that the cortical loss of Nr2f1 impacts on spontaneous network activity and synchronization of S1 cortex at perinatal stages. In addition, we observed alterations in the intrinsic excitability and morphological features of layer V pyramidal neurons. Accordingly, we identified distinct voltage-gated ion channels regulated by Nr2f1 that might directly influence intrinsic bioelectrical properties during critical time windows of S1 cortex specification. Altogether, our data suggest a tight link between Nr2f1 and neuronal excitability in the developmental sequence that ultimately sculpts the emergence of cortical network activity within the immature neocortex.

Language

English

Open access status

closed

Identifiers

DOI 10.1093/cercor/bhaa137
ISSN 1047-3211

Persistent URL

https://sonar.ch/global/documents/29722

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