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The first international workshop on the epigenetics of osteoarthritis.

  • Meulenbelt IM a Department of Medical Statistics and Bioinformatics, Section of Molecular Epidemiology , Leiden University Medical Center , Leiden , The Netherlands.
  • Bhutani N b Department of Orthopaedic Surgery , Stanford University School of Medicine , Stanford , CA , USA.
  • den Hollander W a Department of Medical Statistics and Bioinformatics, Section of Molecular Epidemiology , Leiden University Medical Center , Leiden , The Netherlands.
  • Gay S c Department of Rheumatology , Center of Experimental Rheumatology, University Hospital Zurich , Zurich , Switzerland.
  • Oppermann U d Botnar Research Center, NIHR Oxford Biomedical Research Unit, Nuffield Department of Orthopaedics , Rheumatology and Musculoskeletal Sciences, University of Oxford , Oxford , UK.
  • Reynard LN f Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University , Newcastle-upon-Tyne , UK.
  • Skelton AJ f Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University , Newcastle-upon-Tyne , UK.
  • Young DA f Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University , Newcastle-upon-Tyne , UK.
  • Beier F h Department of Physiology and Pharmacology , Schulich School of Medicine and Dentistry, University of Western Ontario , London , ON , Canada.
  • Loughlin J f Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University , Newcastle-upon-Tyne , UK.
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  • 2016-03-31
Published in:
  • Connective tissue research. - 2017
DNA methylation
epigenetics
histones
osteoarthritis
regulatory RNAs
Animals
Congresses as Topic
Denmark
Epigenomics
Humans
Osteoarthritis
English Osteoarthritis (OA) is a major clinical problem across the world, in part due to the lack of disease-modifying drugs resulting, to a significant degree, from our incomplete understanding of the underlying molecular mechanisms of the disease. Emerging evidence points to a role of epigenetics in the pathogenesis of OA, but research in this area is still in its early stages. In order to summarize current knowledge and to facilitate the potential coordination of future research activities, the first international workshop on the epigenetics of OA was held in Amsterdam in October 2015. Recent findings on DNA methylation and hydroxymethylation, histone modifications, noncoding RNAs, and other epigenetic mechanisms were presented and discussed. The workshop demonstrated the advantage of bringing together those working in this nascent field and highlights from the event are summarized in this report in the form of summaries from invited speakers and organizers.
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  • English
Open access status
hybrid
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https://sonar.ch/global/documents/297252
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