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Activation of the epithelial sodium channel (ENaC) by serine proteases.
Journal article

Activation of the epithelial sodium channel (ENaC) by serine proteases.

  • Rossier BC Department of Pharmacology and Toxicology, University of Lausanne, CH-1005 Lausanne, Switzerland. Bernard.Rossier@unil.ch
  • Stutts MJ
  • 2008-10-22
Published in:
  • Annual review of physiology. - 2009
Animals
Cochlea
Epithelial Sodium Channels
Extracellular Fluid
Humans
Kidney
Lung
Serine Endopeptidases
English The study of human monogenic diseases [pseudohypoaldosteronism type 1 (PHA-1) and Liddle's syndrome] as well as mouse models mimicking the salt-losing syndrome (PHA-1) or salt-sensitive hypertension (Liddle's syndrome) have established the epithelial sodium channel ENaC as a limiting factor in vivo in the control of ionic composition of the extracellular fluid, regulation of blood volume and blood pressure, lung alveolar clearance, and airway mucociliary clearance. In this review, we discuss more specifically the activation of ENaC by serine proteases. Recent in vitro and in vivo experiments indicate that membrane-bound serine proteases are of critical importance in the activation of ENaC in different organs, such as the kidney, the lung, or the cochlea. Progress in understanding the basic mechanism of proteolytic activation of ENaC is accelerating, but uncertainty about the most fundamental aspects persists, leaving numerous still-unanswered questions.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://sonar.ch/global/documents/29741
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