Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
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Swirski, Filip K.
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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Nahrendorf, Matthias
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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Etzrodt, Martin
Faculty of Biology and Medicine, University of Lausanne, CH-1015 Lausanne, Switzerland.
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Wildgruber, Moritz
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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Cortez-Retamozo, Virna
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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Panizzi, Peter
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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Figueiredo, Jose-Luiz
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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Kohler, Rainer H.
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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Chudnovskiy, Aleksey
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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Waterman, Peter
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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Aikawa, Elena
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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Mempel, Thorsten R.
Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
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Libby, Peter
Center for Excellence in Vascular Biology, Brigham and Women’s Hospital, Boston, MA 02115, USA.
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Weissleder, Ralph
Department of Systems Biology, Harvard Medical School, Boston, MA 02115.
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Pittet, Mikael J.
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
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Published in:
- Science. - American Association for the Advancement of Science (AAAS). - 2009, vol. 325, no. 5940, p. 612-616
English
A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry. Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation. The reservoir monocytes assemble in clusters in the cords of the subcapsular red pulp and are distinct from macrophages and DCs. In response to ischemic myocardial injury, splenic monocytes increase their motility, exit the spleen en masse, accumulate in injured tissue, and participate in wound healing. These observations uncover a role for the spleen as a site for storage and rapid deployment of monocytes and identify splenic monocytes as a resource that the body exploits to regulate inflammation.
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Language
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Open access status
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green
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Persistent URL
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https://sonar.ch/global/documents/29884
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