Journal article
Massive uric acid nephrolithiasis with progressive renal failure due to spontaneous tumour lysis syndrome.
- Trachsler J Clinic for Nephrology.
- Gaspert A Department of Pathology.
- Previsdomini M Medical Intensive Care Unit, University Hospital/Zürich Medical School, Zürich , Switzerland.
- Wüthrich RP Clinic for Nephrology.
- Fehr T Clinic for Nephrology.
- 2015-05-19
Published in:
- NDT plus. - 2008
English
Tumour lysis syndrome (TLS) is a constellation of meta- bolic complications due to the rapid destruction of malignant cells, causing renal, cardiac or cerebral dysfunction. Electrolyte abnormalities include hyperuricaemia, hyperphosphataemia, hyperkalaemia and hypocalcaemia. TLS-induced renal failure is mainly caused by uric acid and calcium phosphate crystal deposition and usually develops following cytotoxic chemotherapy. Here, we present a case of spontaneous TLS in a patient with chronic myelomonocytic leukaemia (CMML) with massive uric acid stone and crystal formation and rapidly worsening renal failure. Autopsy revealed underlying tumourous kidney infiltration. Risk factors for occurrence of TLS and current therapeutic management are discussed.
- Language
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- English
- Open access status
- hybrid
- Identifiers
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- DOI 10.1093/ndtplus/sfn133
- PMID 25983919
- Persistent URL
- https://sonar.ch/global/documents/298979
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